Pathogenesis of Crohn's disease.
Pathogenesis of Crohn's disease.
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DOI：
10.12703/p7-44
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ho GT
中科院分区：
文献类型：
--
作者：
Boyapati R;Satsangi J;Ho GT
克罗恩病（CD）是一种典型的常见、复杂疾病，我们对它的认识已经取得了重大进展。我们询问维持肠道粘膜稳态所涉及的生物过程的深层复杂性的能力是支撑这种快速进展的主要压倒性因素。关键研究现在为遗传易感性、免疫功能和肠道微生物群在CD中的相互作用提供了许多新颖和广泛的见解。在这里，我们提供了这些最新进展和新的机械主题的概述，并解决从概念到临床翻译的挑战和前景。
Significant progress in our understanding of Crohn's disease (CD), an archetypal common, complex disease, has now been achieved. Our ability to interrogate the deep complexities of the biological processes involved in maintaining gut mucosal homeostasis is a major over-riding factor underpinning this rapid progress. Key studies now offer many novel and expansive insights into the interacting roles of genetic susceptibility, immune function, and the gut microbiota in CD. Here, we provide overviews of these recent advances and new mechanistic themes, and address the challenges and prospects for translation from concept to clinic.