Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
复制标题
DOI：
10.1002/ijc.27645
复制
发表时间：
2013-02-01
影响因子：
6.4
通讯作者：
Nothlings, Ute
中科院分区：
文献类型：
--
作者：
Schlesinger, Sabrina;Aleksandrova, Krasimira;Nothlings, Ute
一般性肥胖与肝癌和胆道癌的风险呈正相关，但对成年期腹部肥胖或体重增加知之甚少。我们使用多变量考克斯比例风险模型来研究体重、体重指数、腰围和臀围、腰臀比和腰高比（WHtR）、成年期体重变化与肝细胞癌（HCC）、肝内（IBDC）和肝外胆管系统癌[EBDSC包括胆囊癌（GBC）]风险之间的关系，525名男性和女性参加了欧洲癌症和营养研究的前瞻性调查。在巢式病例对照亚组中测量B和C型肝炎病毒状态。在平均8.6年的随访中，发生了177例HCC，58例IBDC和210例EBDSC，包括76例GBC。所有人体测量指标与HCC和GBC的风险呈正相关。WHtR显示与HCC [相对危险度（RR）比较极端三分位数3.51，95%置信区间（95%CI）：2.095.87; ptrend < 0.0001]和GBC（RR：1.56，95%CI：1.122.16，WHtR增加一个单位）最强的相关性。当比较极端三分位数时，成年期体重增加也与HCC呈正相关（RR：2.48，95% CI：1.49 - 4.13;
General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested casecontrol subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.095.87; ptrend < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.122.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.494.13;