The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone.
The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone.
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DOI：
10.3390/ijms24086935
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发表时间：
2023-04-08
影响因子：
5.6
通讯作者：
McGettrick, Helen M.
中科院分区：
文献类型：
--
作者：
Frost, Kathryn;Naylor, Amy J.;McGettrick, Helen M.
骨重塑是一个高度活跃和动态的过程，涉及成骨细胞、破骨细胞及其祖细胞的严格调节，以维持骨吸收和形成的平衡。衰老和炎症是骨重塑失调的危险因素。一旦骨形成和吸收之间的平衡失去，骨量就会受到损害，导致骨质疏松症和佩吉特氏病等疾病。 1-磷酸鞘氨醇信号通路中的关键分子除了在炎症反应中的作用外，还因其在调节骨重塑中的作用而被确定。这篇综述讨论了 S1P 在骨稳态和疾病（包括骨质疏松症、佩吉特氏病和炎性骨丢失）中不同的、在某些情况下相反的作用的积累证据。具体来说，我们描述了当前关于 S1P 在成骨细胞、破骨细胞及其前体在健康和疾病中的功能的、经常相互矛盾的证据，得出的结论是 S1P 可能是骨病的有效生物标志物，也是一种有吸引力的疾病治疗靶点。
Bone remodelling is a highly active and dynamic process that involves the tight regulation of osteoblasts, osteoclasts, and their progenitors to allow for a balance of bone resorption and formation to be maintained. Ageing and inflammation are risk factors for the dysregulation of bone remodelling. Once the balance between bone formation and resorption is lost, bone mass becomes compromised, resulting in disorders such as osteoporosis and Paget’s disease. Key molecules in the sphingosine-1-phosphate signalling pathway have been identified for their role in regulating bone remodelling, in addition to its more recognised role in inflammatory responses. This review discusses the accumulating evidence for the different, and, in certain circumstances, opposing, roles of S1P in bone homeostasis and disease, including osteoporosis, Paget’s disease, and inflammatory bone loss. Specifically, we describe the current, often conflicting, evidence surrounding S1P function in osteoblasts, osteoclasts, and their precursors in health and disease, concluding that S1P may be an effective biomarker of bone disease and also an attractive therapeutic target for disease.
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影响因子：
2.5
作者：
Dobrosak C;Gooi JH
通讯作者：
Gooi JH
影响因子：
--
作者：
Ardawi MM;Rouzi AA;Al-Senani NS;Qari MH;Elsamanoudy AZ;Mousa SA
通讯作者：
Mousa SA
影响因子：
7.3
作者：
De Cunto, Giovanna;Brancaleone, Vincenzo;Roviezzo, Fiorentina
通讯作者：
Roviezzo, Fiorentina
DOI：
10.3390/ph6091145
发表时间：
2013-09-23
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Golan K;Kollet O;Lapidot T
通讯作者：
Lapidot T
影响因子：
14.9
作者：
Choi, Bongkun;Kim, Ji-Eun;Park, Si-On;Kim, Eun-Young;Oh, Soyoon;Choi, Hyuksu;Yoon, Dohee;Min, Hyo-Jin;Kim, Hyung-Ryong;Chang, Eun-Ju
通讯作者：
Chang, Eun-Ju