EARLY NEURON DIFFERENTIATION IN MOUSE OLFACTORY BULB .1. LIGHT-MICROSCOPY
EARLY NEURON DIFFERENTIATION IN MOUSE OLFACTORY BULB .1. LIGHT-MICROSCOPY
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DOI：
10.1002/cne.901460207
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发表时间：
1972-01-01
影响因子：
2.5
通讯作者：
HINDS, JW
中科院分区：
文献类型：
--
作者：
HINDS, JW
Olfactory bulb development in mouse embryos from day 10 of gestation (E10) to E15 was studied with 1 μ plastic sections and Golgi impregnations. Olfactory nerve axons reach the presumptive olfactory bulb region of the cerebral vesicle at E12, the same time that the first young neurons (postmitotic neuroblasts) are seen in the newly‐formed intermediate (mantle) layer. By E14 many of the presumptive mitral cells are oriented tangential to the surface and have grown a long axon that enters the lateral olfactory tract on the surface of the presumptive piriform cortex.The following probable sequence of differentiation of mitral cells was determined from Golgi impregnations of E14 and E15 animals: (1) After regrowth of an internal and external process following rounding up at mitosis, the nucleus and perikaryon of certain ventricular cells migrate into the deepest portion of the intermediate layer and start to re‐orient into a tangential orientation. This stage is called theprimitive radial stage.(2) The growth of tangential processes combined with withdrawal or atrophy of external and internal primitive radial processes follows to produce cells in thepre‐axonic tangential stage. (3) The tangential cells then acquire a long, thin, unbranched process (axon) oriented towards the lateral olfactory tract and a larger, branching process (dendrite) running in the opposite direction. This stage is called thetangential mitral cell stage. (4) Radial re‐orientation of the perikaryon and dendrites of these cells and external migration of the perikaryon results in cells in theradial mitral cell stage.
