Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study
Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study
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DOI：
10.1002/ijc.11519
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发表时间：
2004-01-10
影响因子：
6.4
通讯作者：
Pietinen, P
中科院分区：
文献类型：
--
作者：
Kilkkinen, A;Virtamo, J;Pietinen, P
据推测，膳食前体中肠道微生物群产生的木脂素肠内酯可以预防激素依赖性癌症。我们进行了一项巢式病例对照研究，以检查血清肠内酯浓度与乳腺癌风险之间的关系。通过时间分辨荧光免疫测定法测量血清中的肠内酯浓度，这些血清是在 4 次独立的横断面人口调查中收集的，这些调查来自随访期间（平均 8.0 年）期间诊断出的 206 名乳腺癌女性和 215 名对照者，这些对照者按研究队列、5 岁年龄组和研究区域与病例进行频率匹配。病例和对照受试者之间的平均血清肠内酯浓度 (nmol/l) 没有显着差异 [分别为 25.2 (SD 22.2) 与 24.0 (SD 21.3)]。通过条件 Logistic 回归估计四分位数中肠内酯浓度增加的乳腺癌风险比值比为 1.00（参考）、1.67 (95% CI 0.95-2.95)、1.71 (95% CI 0.96-3.06) 和 1.30 (95% CI 0.73-2.31)，趋势 p 为 0.48。我们的研究结果不支持高血清肠内酯浓度与乳腺癌风险降低相关的假设。 (C) 2003 Wiley-Liss, Inc.
The lignan enterolactone produced by the intestinal microflora from dietary precursors has been hypothesized to protect against hormone-dependent cancers. We conducted a nested case-control study to examine the relationship between serum enterolactone concentration and risk of breast cancer. Enterolactone concentrations were measured by time-resolved fluoroimmunoassay in serum collected at 4 independent cross-sectional population surveys from 206 women with breast cancer diagnosed during follow-up (mean 8.0 years) and from 215 controls frequency-matched to cases by study cohort, 5-year age group and study area. Mean serum enterolactone concentration (nmol/l) did not significantly differ between case and control subjects [25.2 (SD 22.2) vs. 24.0 (SD 21.3), respectively]. Odds ratios for breast cancer risk estimated by conditional logistic regression for increasing concentration of enterolactone in quartiles were 1.00 (referent), 1.67 (95% CI 0.95-2.95), 1.71 (95% CI 0.96-3.06) and 1.30 (95% CI 0.73-2.31), and p for trend was 0.48. Our findings do not support the hypothesis that high serum enterolactone concentration is associated with reduced risk of breast cancer. (C) 2003 Wiley-Liss, Inc.