Synthesis of a bis-azido analogue of acromelic acid for radioisotope-free photoaffinity labeling and biochemical studies
Synthesis of a bis-azido analogue of acromelic acid for radioisotope-free photoaffinity labeling and biochemical studies
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DOI：
10.1016/j.bmcl.2006.01.083
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发表时间：
2006-05-01
影响因子：
2.7
通讯作者：
Suzuki, M
中科院分区：
文献类型：
--
作者：
Sun, P;Wang, GX;Suzuki, M
一种新型的烯丙酸类似物，其苯基具有两种不同类型的叠氮官能团，其中一种是芳香的N-3作为光亲和基团，通过光照射与靶蛋白结合，另一种是烷基N-3作为光解作用的检测基团，通过Staudinger-Bertozzi反应识别连接产物。设计并合成了一种无放射性同位素的生化探针，有望用于类碱受体的研究。(C) 2006 Elsevier Ltd版权所有。
A novel acromelic acid analogue containing a phenyl group possessing two different types of azido functional groups, of which one is the aromatic N-3 acting as a photoaffinity group to bind to a target protein by photoirradiation and the other is alkyl N-3 group which survives photolysis acting as a detecting group through the Staudinger-Bertozzi reaction to identify the ligated product, was designed and synthesized as a radioisotope-free biochemical probe potentially for studies on kainoid receptors. (C) 2006 Elsevier Ltd. All rights reserved.