Subchondral damage after acute transarticular loading: an in vitro model of joint injury.
Subchondral damage after acute transarticular loading: an in vitro model of joint injury.
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急性经关节负荷后软骨下损伤：关节损伤的体外模型。
DOI：
10.1002/jor.1100100603
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
OegemaJr,TR
中科院分区：
文献类型：
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作者：
Vener,MJ;ThompsonJr,RC;Lewis,JL;OegemaJr,TR
完整的犬掌指关节和跖趾关节在体外进行了各种负荷。19个关节发生关节内骨折，平均力为2.4 ± 0.4kN，相应的加载速率为88 ± 23 kN/s。其余29个关节无明显断裂迹象，平均载荷和加载速率分别为1.7 ± 0.9 kN和64 ± 32 kN/s。在骨折标本中，钙化软骨和软骨下骨区的损伤比通过扫描电子显微镜评估时通过肉眼检查初步发现的要广泛得多。在远离大体骨折处发现钙化软骨区的裂纹和相关的台阶位移。这些发现得到了组织学证实。此外，在1.9-2.8 kN载荷范围内的样本中，通常在组织学上识别出定位于钙化软骨区的裂纹，但没有严重断裂。使用压敏薄膜测定的接触面积随着载荷的增加而增加，直至断裂点。该模型断裂时关节软骨表面产生的平均压力≥40 MPa，断裂发生在接触部位。我们的研究结果表明，急性跨关节负荷的失败开始于钙化软骨区，随后涉及软骨下骨和覆盖软骨。这种类型的损伤可能导致关节内骨折后骨关节炎的发展，或在不导致严重骨折的高负荷下。
Intact canine metacarpophalangeal and metatarsophalangeal joints were subjected to a variety of loads in vitro. Intraarticular fracture occurred in 19 joints loaded to an average force of 2.4 ± 0.4 kN with a corresponding loading rate of 88 ± 23 kN/s. The remaining 29 joints were without gross evidence of fracture with an average load and loading rate of 1.7 ± 0.9 kN and 64 ± 32 kN/s, respectively. In the fractured specimens, damage to the zone of calcified cartilage and subchondral bone was much more extensive than was initially evident by gross inspection when assessed by scanning electron microscopy. Cracks with associated step‐off displacement at the zone of calcified cartilage were found distant to the gross fractures. These findings were confirmed histologically. In addition, cracks localized to the zone of calcified cartilage were commonly identified histologically in specimens loaded in the range of 1.9–2.8 kN, but were not grossly fractured. The contact area determined with pressure‐sensitive film increased with increasing load up to the point of fracture. The average pressure generated at the articular cartilage surface at the time of fracture in this model is ≥40 MPa, and the fracture occurred at the contact site. Our findings suggest that failure in acute transarticular loading begins in the zone of calcified cartilage and subsequently involves the subchondral bone and overlying cartilage. This type of injury may contribute to the development of osteoarthritis after intraarticular fracture, or at high loads that do not result in gross fracture.