Hemovigilance network in France:: organization and analysis of immediate transfusion incident reports from 1994 to 1998
Hemovigilance network in France:: organization and analysis of immediate transfusion incident reports from 1994 to 1998
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DOI：
10.1046/j.1537-2995.2002.00202.x
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发表时间：
2002-10-01
期刊：
影响因子：
2.9
通讯作者：
Hervé, P
中科院分区：
文献类型：
--
作者：
Andreu, G;Morel, P;Hervé, P
背景：血液警戒网络已在一些国家引入，以提高对输血相关发病率和死亡率的认识。这里介绍了1994年至1999年3月法国网络的总体组织及其结果。研究设计和方法：血液警戒网络依赖于输血中心和医院的通讯人员，他们分析意外和不正常的输血相关影响，并将输血事件报告（TIR）传输到国家数据库（输血事件报告电子数据管理[GIFIT]）。结果：截至1999年3月1日，GIFIT数据库包含24,234例与血液警戒网络启动至1998年12月31日期间发生的事件相关的tir。该网络直到1996年才全面实施；但此后报告率似乎稳定在每年约7000例（每1000血液成分报告2.5例）。血小板浓缩物报告率最高（4.02/ 1000），其次是红细胞（1.71/1000）和FFP（0.34/ 1000）。细菌污染迅速成为发病和死亡的主要原因（185例，18例死亡）。但是，观察到这类事件随着时间的推移呈现减少的总体趋势，这可归因于采取了若干预防措施。相比之下，在此期间，红细胞输血期间的主要ABO错配率保持不变，并导致6人死亡。在实施普遍减少白细胞后，一些已知与白细胞有关的事件，如非溶血性热性输血反应（NHFTR）和HLA免疫接种，显著减少。结论：血液警戒不仅是分析输血事件的重要工具，也是衡量国家层面新流程或纠正措施效果的重要工具。
BACKGROUND: Hemovigilance networks have been introduced in several countries to improve knowledge of blood transfusion-related morbidity and mortality. The general organization of the French network and its results from 1994 through March 1999 are presented here.STUDY DESIGN AND METHODS: The hemovigilance network relies on blood transfusion centers and hospital correspondents, who analyze unexpected and untoward blood transfusion-related effects and transmit a Transfusion Incident Report (TIR) to a national database (Transfusion Incident Reports Electronic Data Management [GIFIT]).RESULTS: As of March 1, 1999, the GIFIT database contained 24,234 TIRs related to incidents that occurred from the start of the hemovigilance network until December 31, 1998. The network was not fully implemented until 1996; but the reporting rate seems to have since stabilized at approximately 7000 per year (2.5 reports per 1000 blood components). The highest reporting rate is observed with platelet concentrates (4.02/ 1000), followed by RBCs (1.71/1000) and FFP (0.34/ 1000). Bacterial contamination quickly appeared as a major cause of morbidity and mortality (185 cases and 18 fatalities). However, a general trend of reduction in this type of incident was observed over time, which can be attributed to adoption of several preventive measures. In contrast, major ABO mismatchings during RBC transfusion remained at a constant rate throughout this period and accounted for six fatalities. After the implementation of universal WBC reduction, some incidents known to be related to WBCs, such as nonhemolytic febrile transfusion reactions (NHFTR) and HLA immunization, were dramatically reduced.CONCLUSION: Hemovigilance is an important tool not only to analyze blood transfusion incidents, but also to measure the effects of new processes or corrective actions at a national level.