Assembly of aqueous-cored calcium phosphate nanoparticles for drug delivery
Assembly of aqueous-cored calcium phosphate nanoparticles for drug delivery
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DOI：
10.1021/cm040056i
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发表时间：
2004-11-30
影响因子：
8.6
通讯作者：
Ostafin, AE
中科院分区：
文献类型：
--
作者：
Schmidt, HT;Gray, BL;Ostafin, AE
提出了一种水核磷酸钙纳米颗粒的合成策略，该策略结合了易于制备、重现性、尺寸控制、稳定性和平均厚度控制。通过引入“封端”分子羧乙基磷酸（CEPA）实现悬浮液稳定性和壳厚度控制。使用该方法，制备了具有120-185 +/- 50 nm的粒度分布和10 - 40 nm的可预测平均壳厚度的磷酸钙壳悬浮液，其即使在200 mM盐和2.5 g/dL白蛋白的存在下也稳定长达一个月。
A synthesis strategy for aqueous-cored calcium phosphate nanoparticles is presented that combines ease of preparation, reproducibility, size control, stability, and mean thickness control. Suspension stability and shell thickness control were achieved through the introduction of a "capping" molecule, carboxyethylphosphoric acid (CEPA). Using this method, suspensions of calcium phosphate shells were produced with a size distribution of 120-185 +/- 50 nm and predictable mean shell thickness from 10 to 40 nm that were stable up to a month, even in the presence of 200 mMsalt and 2.5 g/dL albumin.