LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator
LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator
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DOI：
10.1016/s1074-7613(00)80455-0
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发表时间：
1998-01-01
期刊：
影响因子：
32.4
通讯作者：
Ware, CF
中科院分区：
文献类型：
--
作者：
Mauri, DN;Ebner, R;Ware, CF
单纯疱疹病毒(HSV)1和2通过将HSV包膜糖蛋白D(GD)附着在细胞疱疹病毒进入介质(Hvem)上而感染活化的T淋巴细胞，hvem是肿瘤坏死因子受体超家族的孤儿成员。在这里，我们证明了HVEM结合了两个细胞配体，分泌型淋巴毒素α(LTα)和LIGHT，一个是肿瘤坏死因子超家族的新成员。LIGHT是一种29 kDa的II型跨膜蛋白，由激活的T细胞产生，它也与LTαβ的受体结合，但不与LTα或LTβ形成复合体。HSV1GO抑制HSVEM与光的相互作用，光和GO干扰HSV1依赖于HSVEM的细胞进入。这表明疱疹病毒GO是一种膜结合的viokine，并将Light-Hvem确立为淋巴毒素细胞因子-受体系统的组成部分。
Herpes simplex virus (HSV) 1 and 2 infect activated T lymphocytes by attachment of the HSV envelope glycoprotein D (gD) to the cellular herpesvirus entry mediator (HVEM), an orphan member of the tumor necrosis factor receptor superfamily. Here, we demonstrate that HVEM binds two cellular ligands, secreted lymphotoxin alpha (LT alpha) and LIGHT, a new member of the TNF superfamily. LIGHT is a 29 kDa type II transmembrane protein produced by activated T cells that also engages the receptor for the LT alpha beta heterotrimer but does not form complexes with either LT alpha or LT beta. HSV1 go inhibits the interaction of HVEM with LIGHT, and LIGHT and go interfere with HVEM-dependent cell entry by HSV1. This characterizes herpesvirus go as a membrane-bound viokine and establishes LIGHT-HVEM as integral components of the lymphotoxin cytokine-receptor system.