FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF FOCAL SEIZURES
FUNCTIONAL MAGNETIC-RESONANCE-IMAGING OF FOCAL SEIZURES
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DOI：
10.1212/wnl.44.5.850
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发表时间：
1994-05-01
期刊：
影响因子：
9.9
通讯作者：
GADIAN, DG
中科院分区：
文献类型：
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作者：
JACKSON, GD;CONNELLY, A;GADIAN, DG
磁共振成像（MRI）现在可以提供具有高空间和时间分辨率的人脑功能图。我们的目的是确定这种非侵入性技术是否也可以映射局灶性癫痫发作期间发生的皮质激活。为了做到这一点，我们使用了传统的1.5特斯拉临床MRI系统的调查，一个4岁的男孩患有频繁的部分运动癫痫发作，他的右侧。我们每隔10分钟采集一次FLASH图像（TE = 60 msec），并通过从临床癫痫发作期间获得的图像中减去基线图像来获得激活图像。功能性磁共振成像显示连续激活与特定的脑回在左半球与每一个连续的五个临床癫痫发作，也在一段时间内，是不相关的可检测的临床癫痫发作。被激活的区域包括结构异常的脑回。我们的结论是，功能性MRI可以提供新的见解动态事件发生在癫痫的大脑和他们的关系，大脑结构。
Magnetic resonance imaging (MRI) can now provide maps of human brain function with high spatial and temporal resolution. We aimed to establish whether this noninvasive technique could also map the cortical activation that occurs during focal seizures. In order to do this, we used a conventional 1.5-tesla clinical MRI system for the investigation of a 4-year-old boy suffering from frequent partial motor seizures of his right side. We acquired FLASH images (TE = 60 msec) every 10 seconds over intervals of 10 minutes and derived activation images by subtracting baseline images from images obtained during clinical seizures. Functional MRI revealed sequential activation associated with specific gyri within the left hemisphere with each of five consecutive clinical seizures, and also during a period that was not associated with a detectable clinical seizure. The activated regions included gyri that were structurally abnormal. We concluded that functional MRI can provide new insights into the dynamic events that occur in the epileptic brain and their relationship to brain structure.