Mapping studies and expression of genes located on human chromosome 11, band q23.
Mapping studies and expression of genes located on human chromosome 11, band q23.
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位于人类 11 号染色体 q23 条带上的基因的绘图研究和表达。
DOI：
10.1159/000132680
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
Kersey,JH
中科院分区：
文献类型：
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作者：
Savage,PD;Jones,C;Silver,J;GeurtsvanKessel,AH;Gonzalez-Sarmiento,R;Palm,L;Hanson,CA;Kersey,JH
染色体易位和缺失可能改变细胞原癌基因，导致细胞改变，这在恶性肿瘤的发病机制中是重要的。11q23区域经常与人类恶性肿瘤有关。利用11q23易位的白血病细胞系和来自该细胞系的体细胞杂交种，我们分析了分配给11q23的五个基因：NCAM、CD3D、CD3E、THY1和ETS1。我们的数据没有证据表明这些基因直接参与了这种白血病，但使我们能够构建人类基因组这个重要区域的部分遗传图谱：11cen-NCAM-CD3([G，D]，E)-//-(ETS1，THY1)-11qter。
Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen—NCAM—CD3([G, D], E)—//—(ETS1, THY1)— 11qter.