Recurrent interactions in local cortical circuits.
Recurrent interactions in local cortical circuits.
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DOI：
10.1038/s41586-020-2062-x
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发表时间：
2020-03
期刊：
影响因子：
64.8
通讯作者：
Svoboda K
中科院分区：
文献类型：
--
作者：
Peron S;Pancholi R;Voelcker B;Wittenbach JD;Ólafsdóttir HF;Freeman J;Svoboda K
大多数皮层突触是局部的和兴奋性的。局部递归电路可以实现放大，允许模式完成和其他计算。皮层回路包含子网络，由具有相似感受野的神经元组成，相对于网络平均水平，其连接性有所提高。编码不同类型信息的皮层神经元在空间上混合并分布在大的大脑体积上，这阻碍了通过单独扰动这些子网络来探测这些子网络功能的实验。本研究采用计算机模拟、光学记录和操作的方法，探讨了触须体感皮层（L）2/3层的周期性耦合在主动触觉辨别中的作用。L2/3的神经回路模型表明，重复性兴奋通过放大来增强感觉信号，但仅适用于连接性提高的子网络。具有高放大率的模型网络对损伤敏感：一些子网络成员的丢失会降低刺激编码。我们通过映射神经元选择性和具有特定选择性的光消融神经元来测试这一预测。在躯体感觉皮层的L2/3中，消融一小部分（10-20，<总数的5%）代表触摸的神经元显著降低了备用触摸表示中的反应，但不是其他表示。消融对神经元的影响最强烈，其刺激反应与消融人群相似，也与网络模型一致。因此，具有相似选择性的皮层神经元之间的重复性驱动了行为过程中的输入特异性放大。
The majority of cortical synapses are local and excitatory. Local recurrent circuits could implement amplification, allowing for pattern completion and other computations. Cortical circuits contain subnetworks, consisting of neurons with similar receptive fields and elevated connectivity relative to the network average. Cortical neurons encoding different types of information are spatially intermingled and distributed over large brain volumes, hampering experiments that probe the function of these subnetwork by perturbing them individually. We used computational modeling, optical recordings and manipulations to probe the function of recurrent coupling in layer (L) 2/3 of vibrissal somatosensory cortex during active tactile discrimination. A neural circuit model of L2/3 revealed that recurrent excitation enhances sensory signals via amplification, but only for subnetworks with elevated connectivity. Model networks with high amplification were sensitive to damage: loss of a few subnetwork members degraded stimulus encoding. We tested this prediction by mapping neuronal selectivity and photoablating neurons with specific selectivity. In L2/3 of the somatosensory cortex, ablating a small proportion (10-20, < 5 % of the total) of neurons representing touch dramatically reduced responses in the spared touch representation, but not other representations. Ablations most strongly impacted neurons with stimulus responses similar to the ablated population, also consistent with network models. Recurrence among cortical neurons with similar selectivity therefore drives input-specific amplification during behavior.
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DOI：
10.3389/fnene.2010.00021
发表时间：
2010-01-01
期刊：
Frontiers in neuroenergetics
影响因子：
--
作者：
Allegra Mascaro, Anna Letizia;Sacconi, Leonardo;Pavone, Francesco S
通讯作者：
Pavone, Francesco S
影响因子：
16.6
作者：
Canty, A. J.;Huang, L.;De Paola, V.
通讯作者：
De Paola, V.
影响因子：
7.8
作者：
Ahrens, Misha B.;Paninski, Liam;Sahani, Maneesh
通讯作者：
Sahani, Maneesh
影响因子：
16.2
作者：
Crochet, Sylvain;Poulet, James F. A.;Petersen, Carl C. H.
通讯作者：
Petersen, Carl C. H.
影响因子：
5.5
作者：
Holmgren, C;Harkany, T;Zilberter, Y
通讯作者：
Zilberter, Y