Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8.
Selecting T cell receptors with high affinity for self-MHC by decreasing the contribution of CD8.
复制标题
通过减少 CD8 的贡献来选择对自身 MHC 具有高亲和力的 T 细胞受体。
DOI：
10.1126/science.1439792
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Peterson,P
中科院分区：
文献类型：
--
作者：
Sherman,LA;Hesse,SV;Irwin,MJ;LaFace,D;Peterson,P
胸腺中 T 细胞库发育过程中的选择性事件包括其受体识别自身主要组织相容性复合体 (MHC) 分子的细胞的正选择，以及与自身 MHC 相互作用具有高亲和力的细胞的负选择（耐受性）。 T 细胞与 I 类 MHC 分子相互作用的亲和力包括 T 细胞受体和 CD8 辅助受体的贡献。因此，通过降低与CD8相互作用的亲和力，其受体对自身MHC具有相对高亲和力的T细胞可以在阴性选择中存活下来。产生了这样的 T 细胞，并且那些与自身 MHC 加抗原反应的 T 细胞也表现出对自身的低亲和力。
Selective events during T cell repertoire development in the thymus include both the positive selection of cells whose receptors recognize self-major histocompatibility complex (MHC) molecules and negative selection (tolerance) of cells whose interaction with self-MHC is of high affinity. The affinity of T cell interactions with class I MHC molecules includes contributions by both the T cell receptor and the CD8 coreceptor. Therefore, by decreasing the affinity of the interaction with CD8, T cells whose receptors have relatively high affinities for self-MHC may survive negative selection. Such T cells were generated and those T cells reactive with self-MHC plus antigen also displayed low affinity for self.