Dendritic cell-targeted vaccines - hope or hype?
Dendritic cell-targeted vaccines - hope or hype?
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DOI：
10.1038/nri3727
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发表时间：
2014-10-01
影响因子：
100.3
通讯作者：
Seder, Robert A.
中科院分区：
文献类型：
--
作者：
Kastenmueller, Wolfgang;Kastenmueller, Kathrin;Seder, Robert A.
开发一种有效的疫苗，激发针对细胞内病原体和癌症的强烈和持久的T细胞应答是一个挑战。增强疫苗接种有效性的一种策略是靶向树突状细胞（DC）。在这篇观点文章中，我们讨论了现有的诱导适应性免疫的DC靶向方法。我们强调了需要解决的关键问题，以推动该领域的发展，并讨论靶向DC是否可能比目前的疫苗方法更好。
The development of an effective vaccine that elicits a strong and durable T cell response against intracellular pathogens and cancer is a challenge. One strategy to enhance the effectiveness of vaccination is by targeting dendritic cells (DCs). In this Opinion article, we discuss existing DC-targeting approaches that induce adaptive immunity. We highlight the crucial issues that need to be addressed to move the field forward and discuss whether targeting DCs could be better than current vaccine approaches.