Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.
Disc in flames: Roles of TNF-α and IL-1β in intervertebral disc degeneration.
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DOI：
10.22203/ecm.v030a08
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发表时间：
2015-09-21
影响因子：
3.1
通讯作者：
Risbud MV
中科院分区：
文献类型：
--
作者：
Johnson ZI;Schoepflin ZR;Choi H;Shapiro IM;Risbud MV
椎间盘是一个重要的机械结构，它允许脊柱的活动范围。由老化、创伤性损伤、遗传倾向或其他因素引起的椎间盘变性通常由组织中的功能和结构变化定义，包括细胞外基质的过度分解、椎间盘细胞衰老和死亡增加以及组织的生物力学功能受损。椎间盘退变与腰痛密切相关，腰痛是一种非常普遍和昂贵的疾病，显著导致生产力和医疗保健成本的损失。椎间盘退变是一种慢性、进行性疾病，目前的治疗方法有限，通常集中在症状性疼痛缓解上，而不是减少疾病的进展。由细胞因子TNF-α和IL-1β加剧的炎症过程被认为是椎间盘退变和腰痛的关键介质。在这篇综述中，我们描述了TNF-α和IL-1β对椎间盘退变过程中细胞和组织水平变化的贡献，新的证据表明脊柱感染和腰痛之间的联系，以及旨在对抗这些过程的新兴治疗方式。
The intervertebral disc is an important mechanical structure that allows range of motion of the spinal column. Degeneration of the intervertebral disc, incited by aging, traumatic insult, genetic predisposition, or other factors, is often defined by functional and structural changes in the tissue, including excessive breakdown of the extracellular matrix, increased disc cell senescence and death, and compromised biomechanical function of the tissue. Intervertebral disc degeneration is strongly correlated with low back pain, which is a highly prevalent and costly condition, significantly contributing to loss in productivity and health care costs. Disc degeneration is a chronic, progressive condition, and current therapies are limited and often focused on symptomatic pain relief rather than curtailing the progression of the disease. Inflammatory processes, exacerbated by cytokines TNF-α and IL-1β are believed to be key mediators of disc degeneration and low back pain. In this review, we describe the contributions of TNF-α and IL-1β to changes seen during disc degeneration at the cellular and tissue level, new evidence suggesting a link between infection of the spine and low back pain, and the emerging therapeutic modalities aimed at combating these processes.