Gender differences in the association between maternal smoking during pregnancy and childhood growth trajectories: multilevel analysis
Gender differences in the association between maternal smoking during pregnancy and childhood growth trajectories: multilevel analysis
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DOI：
10.1038/ijo.2010.198
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Yamagata, Z.
中科院分区：
文献类型：
--
作者：
Suzuki, K.;Kondo, N.;Yamagata, Z.
目的：本研究探讨了母亲在怀孕期间吸烟与儿童后期生长之间的关系的性别差异。设计：正在进行的前瞻性队列研究，被称为“Koshu项目”，从胎儿阶段开始到9-10岁。设置：日本农村地区的Koshu市参与者：研究人群包括1991年4月1日至1999年3月31日在日本Koshu市出生的儿童及其母亲。母亲在怀孕早期吸烟的暴露studied.Main结果的措施：儿童体重指数（BMI）和BMI Z-分数轨迹的儿童出生的吸烟和不吸烟的母亲的性别。多层次分析，包括个人和年龄作为不同层次的变量进行了统计analysis.Results：参与的母亲在研究期间交付了1619名婴儿。从这些儿童中收集了1603名（出生时，99.0%）、1358名（3岁，83.9%）、1248名（5岁，77.1%）、1270名（7-8岁，78.4%）和1274名（9-10岁，78.7%）的出生体重和人体测量数据。母亲孕期吸烟的新生儿平均出生体重均显著低于母亲孕期不吸烟的新生儿（P
Objectives: This study examines the gender differences in the association between maternal smoking during pregnancy and later growth in childhood.Design: Ongoing prospective cohort study, which is called 'the Project Koshu', initiated in the foetal stage to the age of 9-10 years.Setting: Koshu City which was in Japanese rural areaParticipants: The study population comprised children born between 1 April 1991 and 31 March 1999 in Koshu City, Japan, and their mothers. Maternal smoking during early pregnancy was the exposure studied.Main outcome measures: Childhood body mass index (BMI) and BMI z-score trajectories of the children born to the smoking and non-smoking mothers by gender. Multilevel analysis that includes both individual and age as different-level variables was used for statistical analyses.Results: The participating mothers delivered 1619 babies during the study period. Birth weight and anthropometric data were collected from 1603 (at birth, 99.0%), 1358 (at age 3, 83.9%), 1248 (at age 5, 77.1%), 1270 (at age 7-8, 78.4%) and 1274 (at age 9-10, 78.7%) of these children. The mean birth weight of both the male and female children whose mothers had smoked during pregnancy was significantly low compared with those born to non-smoking mothers (P