Peripheral or central administration of nitric oxide synthase inhibitor affects feeding behavior in chicks
Peripheral or central administration of nitric oxide synthase inhibitor affects feeding behavior in chicks
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DOI：
10.1016/j.cbpa.2007.06.006
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发表时间：
2007-10-01
影响因子：
2.3
通讯作者：
Ueda, Hiroshi
中科院分区：
文献类型：
--
作者：
Khan, Md. Sakirul Islam;Tachibana, Tetsuya;Ueda, Hiroshi
研究了一氧化氮（NO）合酶抑制剂N-硝基-L-精氨酸甲酯（N-G-nitro-L-arginine methyl ester，L-NAME）外周或中枢给药对蛋鸡和肉仔鸡（Gallus gallus）采食量的影响。腹腔注射L-NAME可显著降低肉仔鸡和产蛋鸡的采食量，而腹腔注射L-NAME可显著降低产蛋鸡的采食量。给予D-NAME（L-NAME的一种非活性形式）没有效果。侧脑室（ICV）注射L-NAME不影响肉仔鸡的摄食量。但侧脑室注射L-NAME可增加蛋鸡的采食量，而注射D-NAME则无此作用。除此之外，L-NAME诱导的摄食与L-精氨酸的共同注射是否定的，这表明NO作为一种摄食抑制信号在蛋鸡的大脑。本研究表明，注射NO合酶抑制剂可影响雏鸡的采食量，但这种影响可能因鸡种和注射部位而异。(C)2007年爱思唯尔公司All rights reserved.
We investigated the effect of peripheral or central administration of N-G-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, on food intake in layer and broiler chicks (Gallus gallus). The intraperitoneal administration of L-NAME significantly decreased food intake in both broiler and layer chicks while the. administration of D-NAME, an inactive form of L-NAME, had no effect. The intracerebroventricular (ICV) injection of L-NAME did not affect food intake in broiler chicks. However, ICV injection of L-NAME increased food intake in layer chicks while the injection of D-NAME had no effect. In addition to this, L-NAME-induced feeding was negated with the co-injection of L-arginine, suggesting that NO acts as a feeding-inhibitor signal in the brain of layer chicks. The present study revealed that administration of NO synthase inhibitor affected food intake in chicks, but the effect might be changed by chick strain and position of the injection. (C) 2007 Elsevier Inc. All rights reserved.