3-O-METHYLDOPA BLOCKS DOPA METABOLISM IN RAT CORPUS STRIATUM
3-O-METHYLDOPA BLOCKS DOPA METABOLISM IN RAT CORPUS STRIATUM
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DOI：
10.1002/ana.410120310
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发表时间：
1982-01-01
影响因子：
11.2
通讯作者：
FAHN, S
中科院分区：
文献类型：
--
作者：
RECHES, A;FAHN, S
3‐O‐Methyldopa (OMD) given to rats inhibits striatal uptake and utilization ofL‐dopa. Thus, the accumulation ofL‐dopa, dopamine, 3,4‐dihydroxyphenylacetic acid, and homovanillic acid in OMD‐pretreated rats afterL‐dopa injection is significantly lower compared with control rats. This effect of OMD is dose dependent. OMD inhibitsL‐dopa accuumlation in the striatum after inhibition of aromatic amino acid decarboxylase activity with 3‐hydroxybenzylhydrazine‐HCL. This effect is not mediated through inhibition of firing in dopaminergic neurons, since the accumulation of dopamine in the striatum after γ‐butyrolactone injection was also significantly reduced by OMD. It is suggested that OMD competes withL‐dopa and tyrosine uptake into the brain. These findings are in line with clinical observations which indicate that high plasma levels of OMD in parkinsonian patients are associated with poor response toL‐dopa. The data presented here indicate that use of catechol‐O‐methyltransferase inhibitors withL‐dopa may be of value in the treatment of parkinsonian patients.
