A data-rich recruitment core to support translational clinical research.

A data-rich recruitment core to support translational clinical research.
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DOI:
10.1111/cts.12240
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发表时间:
2015-04
期刊:
Clinical and translational science
影响因子:
--
通讯作者:
Coller BS
Coller BS
中科院分区:
其他
文献类型:
--
作者:
Kost RG;Corregano LM;Rainer TL;Melendez C;Coller BS

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临床研究招募不足浪费了资源,延误了对研究发现的评估。我们描述了一个集中的招聘核心提供全面的招聘支持调查的组织和影响。洛克菲勒大学临床和转化科学中心支持集中招聘核心、呼叫中心、研究志愿者库、数据基础设施和为研究者提供专家招聘服务的工作人员。在方案制定过程中,咨询旨在优化招募可行性、制定招募策略、预算和广告。研究开展期间的服务包括广告投放、储存库查询、呼叫管理、预筛选、转诊和访视安排。使用专用软件跟踪利用率和征聘结果。对于2009-2013年期间接受招募服务的方案:从招募开始到首例入组受试者的中位时间为10天;在4,047名首次致电呼叫中心的受试者中,92%(n=3722)在研究志愿者库中登记,保留率为99%; 23%的储存库入组者随后入组了≥1项研究,保留率为89%。在通过存储库查询转介的志愿者中,49%(280/537)入组研究,92%保留。提供强大的招聘基础设施,包括专业知识、志愿者资料库、数据采集和实时分析,可加速方案的累积。应用招募科学提高临床研究质量。
Under-enrollment of clinical studies wastes resources and delays assessment of research discoveries. We describe the organization and impact of a centralized recruitment core delivering comprehensive recruitment support to investigators. The Rockefeller University Center for Clinical and Translational Science supports a centralized recruitment core, call center, Research Volunteer Repository, data infrastructure, and staff who provide expert recruitment services to investigators. During protocol development, consultations aim to optimize enrollment feasibility, develop recruitment strategy, budget, and advertising. Services during study conduct include advertising placement, repository queries, call management, prescreening, referral, and visit scheduling. Utilization and recruitment outcomes are tracked using dedicated software. For protocols receiving recruitment services during 2009–2013: median time from initiation of recruitment to the first enrolled participant was 10 days; of 4,047 first-time callers to the call center, 92% (n=3722) enrolled in the Research Volunteer Repository, with 99% retention; 23% of Repository enrollees subsequently enrolled in ≥1 research studies, with 89% retention. Of volunteers referred by repository queries, 49% (280/537) enrolled into the study, with 92% retained. Provision of robust recruitment infrastructure including expertise, a volunteer repository, data capture and real-time analysis accelerates protocol accrual. Application of recruitment science improves the quality of clinical investigation.
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