The vascular biology of macrophage migration inhibitory factor (MIF) Expression and effects in inflammation, atherogenesis and angiogenesis
The vascular biology of macrophage migration inhibitory factor (MIF) Expression and effects in inflammation, atherogenesis and angiogenesis
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DOI：
10.1160/th12-11-0831
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发表时间：
2013-03-01
影响因子：
6.7
通讯作者：
Bernhagen, Juergen
中科院分区：
文献类型：
--
作者：
Asare, Yaw;Schmitt, Martin;Bernhagen, Juergen
巨噬细胞迁移抑制因子（MIF）是一种具有趋化因子样功能的多效性细胞因子。 MIF 是宿主免疫和炎症反应的关键介质。已证明 MIF 表达失调会导致各种急性和慢性炎症以及癌症的发生。最近，MIF 已被确定为重要的促动脉粥样硬化因子。它的阻断甚至可以帮助晚期动脉粥样硬化的斑块消退。促进致动脉粥样硬化的白细胞募集过程已被认为是血管病理学中 MIF 的主要潜在机制。然而，MIF 在血管生物学中的作用不仅限于小鼠细胞募集，因为最近的证据还表明，这种 I 介体通过内皮细胞激活和内皮祖细胞募集在新血管生成/血管生成中发挥作用。本文在介绍MIF类趋化因子功能的基础上，重点阐述MIF在血管生物学和病理学中的作用。
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with chemokine-like functions. MIF is a critical mediator of the host 'immune and inflammatory response. Dysregulated MIF expression has been demonstrated to contribute to various acute and chronic inflammatory conditions as well as cancer development. More recently, MIF has been identified as an important pro-atherogenic factor. Its blockade could even aid plaque regression in advanced atherosclerosis. Promotion of atherogenic leukocyte recruitment processes has been recognised as a major underlying mechanism of MIF in vascular pathology. However, MIF's role in vascular biology is not limited to mune cell recruitment as recent evidence also points to a role for this I mediator in neo-angiogenesis / vasculogenesis by endothelial cell activation and endothelial progenitor cell recruitment. On the basis of introducing MIF's chemokine-like functions, the current article focusses on MIF's role in vascular biology and pathology.