The role of the dorsomedial striatum in instrumental conditioning
The role of the dorsomedial striatum in instrumental conditioning
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DOI：
10.1111/j.1460-9568.2005.04218.x
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发表时间：
2005-07-01
影响因子：
3.4
通讯作者：
Balleine, BW
中科院分区：
文献类型：
--
作者：
Yin, HH;Ostlund, SB;Balleine, BW
大量证据表明，在工具调节中，老鼠学习行为与其特定后果或结果之间的关系。本研究探讨了背内侧纹状体（DMS）在兴奋性毒性损伤和可逆性蝇蕈醇诱导失活后的此类学习中的作用。在三个实验中，首先训练老鼠按下两个杠杆以获得不同的结果，然后在训练后使用各种已建立的用于检测行动结果学习的行为分析进行测试。在实验1中，后部DMS的训练前损伤消除了大鼠在灭绝测试中仪器表现对结果贬值和意外退化的敏感性，而前部DMS的损伤则没有影响。在实验 2 中，后 DMS 的训练前和训练后损伤在降低性能对贬值和退化治疗的敏感性方面同样有效。在实验3中，将蝇蕈醇注入后DMS选择性地消除了表现对贬值和意外退化的敏感性，而不会损害大鼠区分所执行的工具性动作或所获得结果的能力。总而言之，这些结果表明 DMS 的后部区域是器乐调节中动作与结果关联的获取和表达的关键神经基质。
Considerable evidence suggests that, in instrumental conditioning, rats learn the relationship between actions and their specific consequences or outcomes. The present study examined the role of the dorsomedial striatum (DMS) in this type of learning after excitotoxic lesions and reversible, muscimol-induced inactivation. In three experiments, rats were first trained to press two levers for distinct outcomes, and then tested after training using a variety of behavioural assays that have been established to detect action-outcome learning. In Experiment 1, pre-training lesions of the posterior DMS abolished the sensitivity of rats' instrumental performance to both outcome devaluation and contingency degradation when tested in extinction, whereas lesions of the anterior DMS had no effect. In Experiment 2, both pre-training and post-training lesions of the posterior DMS were equally effective in reducing the sensitivity of performance both to devaluation and degradation treatments. In Experiment 3, the infusion of muscimol into the posterior DMS selectively abolished sensitivity of performance to devaluation and contingency degradation without impairing the ability of rats to discriminate either the instrumental actions performed or the identity of the earned outcomes. Taken together, these results suggest that the posterior region of the DMS is a crucial neural substrate for the acquisition and expression of action-outcome associations in instrumental conditioning.