Relationship between structural abnormalities in the cerebellum and dementia, posttraumatic stress disorder and bipolar disorder
Relationship between structural abnormalities in the cerebellum and dementia, posttraumatic stress disorder and bipolar disorder
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DOI：
10.1590/s1980-57642012dn06040003
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发表时间：
2012-12-01
期刊：
影响因子：
--
通讯作者：
Jackowski, Andrea Parolin
中科院分区：
文献类型：
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作者：
Baldaçara, Leonardo;Borgio, João Guilherme Fiorani;Jackowski, Andrea Parolin
新的证据表明小脑在精神疾病中存在结构和功能异常。 目的：在这项研究中，目的是测量精神疾病个体的小脑及其分区的体积，并将这些结果与他们的症状联系起来。 方法：对来自人群研究的不同程度的认知障碍患者（老年人流行病学 - UNIFESP）和创伤后应激障碍（PTSD）患者进行分析。此外，本研究还招募了来自门诊诊所（巴伊亚联邦大学情绪和焦虑症研究中心）的双相情感障碍患者。所有受试者均接受 1.5T 结构磁共振扫描。通过心理测量量表进行体积测量和症状测量，并在患者和对照组之间进行比较。结果：与对照组相比，无痴呆和患有痴呆的认知障碍患者、PTSD 患者和双相情感障碍患者的小脑体积有所减小。在痴呆和创伤后应激障碍中，左侧小脑半球和蚓部体积减小。在双相情感障碍中，大脑半球和蚓部的体积均减少。在前两项研究中，这些小脑体积的减少与疾病的症状相关。结论：小脑参与心理过程的确切性质仍不完全清楚。然而，在其中一些疾病中已经报道了小脑结构及其功能的异常。未来需要进行更大样本的研究来阐明这些发现并调查它们对治疗和预后是否重要。
New evidence suggests that the cerebellum has structural and functional abnormalities in psychiatric disorders.OBJECTIVE: In this research, the goal was to measure the volume of the cerebellum and its subregions in individuals with psychiatric disorders and to relate these findings to their symptoms.METHODS: Patients with different degrees of cognitive impairment (Epidemiology of the Elderly - UNIFESP) and patients with post-traumatic stress disorder (PTSD) from population studies were analyzed. Also, patients with bipolar disorder from an outpatient clinic (Center for the Study of Mood and Anxiety Disorders, Universidade Federal da Bahia) were recruited for this study. All subjects underwent a 1.5T structural magnetic resonance scan. Volumetric measures and symptom measurements, by psychometric scales, were performed and compared between patients and controls.RESULTS: The cerebellum volume was reduced in patients with cognitive impairment without dementia and with dementia, in patients with PTSD, and in patients with bipolar disorder compared to controls. In dementia and PTSD, the left cerebellar hemisphere and vermis volume were reduced. In bipolar disorder, volumes of both hemispheres and the vermis were reduced. In the first two studies, these cerebellar volumetric reductions correlated with symptoms of the disease.CONCLUSION: The exact nature of cerebellar involvement in mental processes is still not fully understood. However, abnormalities in cerebellar structure and its functions have been reported in some of these diseases. Future studies with larger samples are needed to clarify these findings and investigate whether they are important for treatment and prognosis.