Myasthenia gravis at the crossroad of COVID-19: focus on immunological and respiratory interplay.
Myasthenia gravis at the crossroad of COVID-19: focus on immunological and respiratory interplay.
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新冠肺炎十字路口的重症肌无力：关注免疫学和呼吸系统的相互作用。
DOI：
10.1007/s13760-021-01612-6
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发表时间：
2021-06
影响因子：
2.7
通讯作者：
Marchioni A
中科院分区：
文献类型：
--
作者：
Galassi G;Marchioni A
由新型冠状病毒（SARS-CoV-2）引起的新型冠状病毒病2019 （COVID-19）已成为全球大流行威胁。据报道，由SARS-CoV-2引起的COVID-19于2019年12月起源于中国武汉，并在全球迅速传播。SARS-CoV-2在结构上与其他冠状病毒相似，可引起严重呼吸综合征（SARS-CoV）和中东呼吸综合征（MERS-CoV），两者均与血管紧张素转换酶2 （ACE2）受体结合进入人体细胞。ACE 2在包括神经组织在内的多种细胞中广泛表达。COVID-19表现为发烧和呼吸道症状，可能导致急性呼吸窘迫（ARDS），但有几份已发表的报告显示，急性脑血管疾病、癫痫发作、嗅觉和味觉功能障碍、孤立性脑神经受累、肌炎/下肢肌肉萎缩以及肌无力危象（MC）和吉兰-巴罗综合征（GBS）。在COVID-19大流行期间描述的ARDS，加上重症肌无力（MG）发生的呼吸肌衰竭，可能导致危及生命的疾病，对重症医师、肺科医生和神经科医生具有挑战性。感染被认为是MG恶化和危象的触发因素，在本次COVID-19大流行期间，MG患者的死亡率可能高于普通人群。我们回顾了COVID-19大流行期间MG的现有知识状况，重点关注这两种疾病之间的免疫和呼吸相互作用。
Coronavirus disease 2019 (COVID-19), a disease caused by the novel betacoronavirus (SARS-CoV-2) has become a global pandemic threat. COVID-19 caused by SARS-CoV-2 is reported to originate in December 2019 in Wuhan, China and spreading rapidly around world. SARS-CoV-2 is structurally similar to the other coronaviruses, causing the severe respiratory syndrome (SARS-CoV) and the middle east respiratory syndrome (MERS-CoV), both binding to the angiotensin-converting enzyme 2 (ACE2) receptor to enter human cells. ACE 2 is widely expressed in several cells including, neural tissue. COVID-19 presents with fever and respiratory symptoms, possibly leading to acute respiratory distress (ARDS) but there are several published reports of acute cerebrovascular diseases, seizures, olfactory and gustatory dysfunctions, isolated involvement of cranial nerves, myositis/rabdhomyolisis as well myasthenic crisis (MC) and Guillain–Barré syndrome (GBS). The ARDS described during COVID-19 pandemic, coupled with respiratory muscle failure occurring in myasthenia gravis (MG), may result in a life-threatening condition, challenging for intensivists, pulmonologists and neurologists. Infections are recognized trigger of exacerbations and crisis in MG and patients with MG probably exhibit a mortality higher than the general population during this COVID-19 pandemic. We review the current state of knowledge on MG during the COVID-19 pandemic to focus the immunological and respiratory interplay between these two conditions.
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影响因子：
3.4
作者：
Huber M;Rogozinski S;Puppe W;Framme C;Höglinger G;Hufendiek K;Wegner F
通讯作者：
Wegner F
影响因子：
24.3
作者：
Franco, Cosimo;Facciolongo, Nicola;Nava, Stefano
通讯作者：
Nava, Stefano
DOI：
10.1016/s2213-2600(20)30370-2
发表时间：
2020-12
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Grasselli G;Tonetti T;Protti A;Langer T;Girardis M;Bellani G;Laffey J;Carrafiello G;Carsana L;Rizzuto C;Zanella A;Scaravilli V;Pizzilli G;Grieco DL;Di Meglio L;de Pascale G;Lanza E;Monteduro F;Zompatori M;Filippini C;Locatelli F;Cecconi M;Fumagalli R;Nava S;Vincent JL;Antonelli M;Slutsky AS;Pesenti A;Ranieri VM;collaborators
通讯作者：
collaborators
影响因子：
3.8
作者：
Aguilo-Seara, Gabriela;Xie, Yanchen;Kaminski, Henry J.
通讯作者：
Kaminski, Henry J.
影响因子：
1.4
作者：
Godoy, Daniel Agustin;Mello, Leonardo Jardim Vaz de;Napoli, Mario Di
通讯作者：
Napoli, Mario Di