EOSINOPHILS, BRONCHIAL HYPERREACTIVITY AND LATE-PHASE ASTHMATIC REACTIONS
EOSINOPHILS, BRONCHIAL HYPERREACTIVITY AND LATE-PHASE ASTHMATIC REACTIONS
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DOI：
10.1111/j.1365-2222.1985.tb02290.x
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
KAY, AB
中科院分区：
文献类型：
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作者：
DURHAM, SR;KAY, AB
我们测量了 11 名患有过敏原诱发迟期反应的哮喘患者的气道反应性（乙酰甲胆碱 PC20）和血液嗜酸性粒细胞。攻击前，血液嗜酸性粒细胞与乙酰甲胆碱 PC20 之间存在显着的负相关（P < 0.05）。吸入过敏原后，24 小时嗜酸性粒细胞计数显着升高（P < 0.01）。在出现单一早期反应的患者中没有观察到血液嗜酸性粒细胞计数的增加。晚期应答者中嗜酸性粒细胞计数的变化幅度（24小时减去攻击前值）也与基线甲胆碱PC20相关（P < 0.01）。这些观察结果表明，在出现晚期哮喘反应的受试者中，嗜酸性粒细胞和气道反应性之间可能存在直接关联。
We have measured airways reactivity (methacholine PC20) and blood eosinophils in eleven asthmatics with allergen-induced late-phase reactions. Before challenge there was a significant (P < 0.05) inverse correlation between blood eosinophils and the methacholine PC20. After allergen inhalation eosinophil counts were significantly (P < 0.01) elevated at 24 hr. These increases in blood eosinophil counts were not observed in patients who developed single early responses. The magnitude of the changes in eosinophil counts (24 hr minus pre-challenge values) also correlated with the baseline methanocholine PC20 (P < 0.01) in the late-phase responders. These observations suggest that there may be a direct association between eosinophils and airway reactivity in subjects who develop late-phase asthmatic reactions.