The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control.
The sensory insular cortex mediates the stress-buffering effects of safety signals but not behavioral control.
复制标题
感觉岛叶皮层介导安全信号的压力缓冲作用，但不介导行为控制。
DOI：
10.1523/jneurosci.4270-08.2008
复制
发表时间：
2008-12-10
影响因子：
5.3
通讯作者：
Maier, Steven F.
中科院分区：
文献类型：
--
作者：
Christianson, John P.;Benison, Alexander M.;Jennings, Joshua;Sandsmark, Emilee K.;Amat, Jose;Kaufman, Richard D.;Baratta, Michael V.;Paul, Evan D.;Campeau, Serge;Watkins, Linda R.;Barth, Daniel S.;Maier, Steven F.
关键词：
安全信号是预测无压力时期的学习线索，而行为控制是通过行为行为改变压力源的能力。两者都可以减轻压力源的影响，例如无法控制的冲击。控制行为产生的内部和外部线索之后是无压力间隔，因此安全学习可能是控制效果的基础。如果是这种情况，那么行为控制和安全应该采用相同的神经机制。有趣的是，阻止压力源暴露的行为结果的安全信号也被控制（减少社会探索）所阻止，但未能抑制中缝背核的活动或利用腹内侧前额叶皮层（行为控制的机制）。然而，后岛叶皮质区域（称为“感觉岛叶”）的双侧损伤阻止了安全性的影响，但没有阻止行为控制的影响，从而提供了双重解离。这些结果表明，压力源调节器可以招募不同的神经回路，并暗示感觉岛叶在安全学习中发挥着关键作用。
Safety signals are learned cues that predict stress-free periods while behavioral control is the ability to modify a stressor by behavioral actions. Both serve to attenuate the effects of stressors such as uncontrollable shocks. Internal and external cues produced by a controlling behavior are followed by a stressor-free interval, and so it is possible that safety learning is fundamental to the effect of control. If this is the case then behavioral control and safety should recruit the same neural machinery. Interestingly, safety signals that prevented a behavioral outcome of stressor exposure that is also blocked by control (reduced social exploration) failed to inhibit activity in the dorsal raphé nucleus or utilize the ventromedial prefrontal cortex, the mechanisms by which behavioral control operates. However, bilateral lesions to a region of posterior insular cortex, termed the “sensory insula,” prevented the effect of safety but not of behavioral control, providing a double-dissociation. These results indicate that stressor-modulators can recruit distinct neural circuitry and imply a critical role of the sensory insula in safety learning.