Biomimetic Metal-Chalcogenide Agents Enable Synergistic Cancer Therapy via Microwave Thermal-Dynamic Therapy and Immune Cell Activation.
Biomimetic Metal-Chalcogenide Agents Enable Synergistic Cancer Therapy via Microwave Thermal-Dynamic Therapy and Immune Cell Activation.
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仿生金属硫属化物试剂通过微波热动力疗法和免疫细胞激活实现协同癌症治疗。
DOI：
10.1021/acsami.3c05728
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发表时间：
2023-08
影响因子：
9.5
通讯作者：
Xiaomu Xu;Qiong Wu;Longfei Tan;Xianwei Men;Yue Huang;Hong Li
中科院分区：
文献类型：
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作者：
Xiaomu Xu;Qiong Wu;Longfei Tan;Xianwei Men;Yue Huang;Hong Li
微波热动力疗法（Microwave Thermal Dynamic Therapy，MTDT）是一种将微波热效应与活性氧（reactive oxygen species，ROS）激活结合起来的治疗肿瘤的新方法。多功能药物的协同作用是肿瘤局部治疗的关键。在这项研究中，研究了一种基于ZIF-67的治疗诊断剂，该治疗诊断剂装载有金属硫属化物开放框架3（MCOF 3）和热休克蛋白70（HSP 70）作为内部组分，与靶向癌细胞膜（TCM）结合作为仿生外壳。我们发现，MCOF 3中的金属离子使复合剂表现出过氧化物样活性，产生·OH并破坏癌细胞。然后，使用ZIF-67的微波（MW）热敏剂将MW能量特异性地转化为热能，并通过细胞靶向选择性地加热肿瘤。此外，连续微波热疗还能促进HSP 70的表达，进一步激活CD 4 T细胞和CD 8 α T细胞的效应细胞。因此，由于MTDT和免疫细胞活化的协同作用，所述试剂在体外和体内有效地抑制MW照射下的肿瘤细胞生长。该研究为有效消融癌症提供了一种新兴策略。
Microwave thermal dynamic therapy (MTDT), which combines thermal effects and reactive oxygen species (ROS) by microwave activation, seems to be a promising anticancer therapeutic method. A multifunctional agent for achieving synergistic localized cancer treatment is the key to exploit the strategy to inhibit tumor cell recurrence and metastasis. In the study, a ZIF-67 based theranostic agent loaded with metal-chalcogenide open framework 3 (MCOF3) and heat shock protein 70 (HSP70) as the inner component was studied, coupled with targeting cancer cell membrane (TCM) as the biomimetic outer shell. We found that metal ions in MCOF3 enabled the composite agents to show peroxide-like activity to produce •OH and destroy cancer cells. And then, the microwave (MW) thermal sensitizer of ZIF-67 was used to specifically convert the MW energy into thermal energy and selectively heat the tumor via the cell's targeting. Additionally, the effect of continuous MW thermal therapy has been shown to promote the expression of HSP70, and further activate the effector of CD4 T cell and CD8α T cell. As such, the agents effectively inhibit the tumor cell growth under MW irradiation in vitro and in vivo due to the synergistic effects of MTDT and immune cell activation. The study provides an emerging strategy to ablation cancer effectively.