Recruitment and blocking properties of the CardioFit stimulation lead
Recruitment and blocking properties of the CardioFit stimulation lead
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DOI：
10.1088/1741-2560/8/3/034004
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发表时间：
2011-06-01
影响因子：
4
通讯作者：
Goldberg, Joshua A.
中科院分区：
文献类型：
--
作者：
Anholt, Tamar Ahilea;Ayal, Shai;Goldberg, Joshua A.
这种迷走神经刺激系统已被开发为一种治疗充血性心力衰竭(CHF)的建议疗法。参加INOVATE-HF临床试验的数百名CHF患者将植入心脏Fit，这是FDA批准的一项研究。心脏紧贴刺激导联(CSL)是一种袖带电极，将刺激脉冲传递到右侧颈迷走神经，旨在招募心脏迷走神经传出纤维，同时最大限度地减少其他纤维的不必要招募。本文介绍了CSL及其在含氧人工脑脊液中高温保存的猪离体迷走神经上的募集和阻断特性的测量。使用电荷平衡的准梯形脉冲驱动CSL，我们在9条神经中有8条在3.0+/-0.8 mA的电流下，A纤维复合动作电位的单向衰减达到63%+/-13%(平均+/-SD)。A和B纤维的激活阈值分别为0.3+/-0.17 mA和2.5+/-1.1 mA。这里介绍的结果应该有助于指导即将部署的心脏配对系统所使用的最佳参数。
The CardioFit vagal stimulation system has been developed as a proposed therapy for congestive heart failure (CHF). CardioFit is to be implanted in several hundred CHF patients enrolled in the INOVATE-HF clinical trial, an FDA approved study. The CardioFit stimulation lead (CSL), which is a cuff electrode that delivers stimulation pulses to the right cervical vagus, was designed to recruit efferent cardiac vagal fibers while minimizing unwanted recruitment of other fibers. This paper presents the CSL and measurements of its recruiting and blocking properties when placed on isolated porcine vagus nerves maintained at an elevated temperature in oxygenated artificial cerebrospinal fluid. Using charge balanced quasi-trapezoidal pulses driven through the CSL, we show in eight out of nine nerves a 63% +/- 13% (mean +/- SD) unidirectional attenuation of the A-fiber compound action potential attained at a current of 3.0 +/- 0.8 mA. The threshold for the activation of A- and B-fibers was found to be 0.3 +/- 0.17 mA and 2.5 +/- 1.1 mA, respectively. The results presented here should help to guide the optimal parameters used in the upcoming deployment of the CardioFit system.