Transient receptor potential channels in the inner ear: Presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear
Transient receptor potential channels in the inner ear: Presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear
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DOI：
10.1080/00016480510038572
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发表时间：
2005-09-01
影响因子：
1.4
通讯作者：
Anniko, M
中科院分区：
文献类型：
--
作者：
Takumida, M;Kubo, N;Anniko, M
结论。本研究结果提示，瞬时受体电位亚家族1(TRPV1)可能在感觉细胞生理学中起着重要作用，而TRPV4可能对内耳的液体稳态起重要作用。目标。分析TRPV1和-4在正常豚鼠内耳组织中的表达。材料和方法。实验动物为白化豚鼠。用免疫组织化学方法研究了TRPV1和-4在内耳即耳蜗器、前庭终器和内淋巴囊中的定位。结果。免疫组织化学显示TRPV1表达于Corti器的毛细胞和支持细胞、螺旋神经节细胞、前庭终器的感觉细胞和前庭神经节细胞。TRPV4阳性细胞见于Corti器官的毛细胞和支持细胞、血管纹边缘细胞、螺旋神经节细胞、感觉细胞、移行细胞、前庭终器暗细胞、前庭神经节细胞和内淋巴囊上皮细胞。
Conclusion. The results of this study indicate that transient receptor potential subfamily 1 ( TRPV1) may play a functional role in sensory cell physiology and that TRPV4 may be important for fluid homeostasis in the inner ear. Objective. To analyze the expression of TRPV1 and - 4 in the normal guinea pig inner ear. Material and methods. Albino guinea pigs were used. The location of TRPV1 and - 4 in the inner ear, i. e. cochlea, vestibular end organs and endolymphatic sac, was investigated by means of immunohistochemistry. Results. Immunohistochemistry revealed the presence of TRPV1 in the hair cells and supporting cells of the organ of Corti, in spiral ganglion cells, sensory cells of the vestibular end organs and vestibular ganglion cells. TRPV4 was found in the hair cells and supporting cells of the organ of Corti, in marginal cells of the stria vascularis, spiral ganglion cells, sensory cells, transitional cells, dark cells in the vestibular end organs, vestibular ganglion cells and epithelial cells of the endolymphatic sac.