A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.
A new rat mutant with defective overhairs and spongy degeneration of the central nervous system: clinical and pathologic studies.
复制标题
一种新的大鼠突变体，具有缺陷的过毛和中枢神经系统的海绵状变性：临床和病理学研究。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
F. Deerberg
中科院分区：
文献类型：
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作者：
S. Rehm;P. Mehraein;Anzil Ap;F. Deerberg
在一群SpragueDawley大鼠中发现了一种新的自发性常染色体隐性突变，伴有神经障碍和毛发异常。这些动物在大约15天大的时候出现全身震颤，随着年龄的增长，出现了进行性的松弛麻痹。光学显微镜显示中枢神经系统有海绵状改变。该突变体被命名为Zitter鼠(ZI)。
A new spontaneous autosomal recessive mutation with a nervous disorder and a hair anomaly occurred in a colony of Sprague Dawley rats. The animals developed a generalized body tremor at about 15 days of age, and with increasing age a progressive flaccid paresis occurred. Light microscopy revealed spongy changes in the central nervous system. The mutant was designated zitter rat (zi).