Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity
Fabrication of Ag and Ta co-doped amorphous calcium phosphate coating films by radiofrequency magnetron sputtering and their antibacterial activity
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DOI：
10.1016/j.msec.2019.110599
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发表时间：
2020-04-01
影响因子：
7.9
通讯作者：
Narushima, Takayuki
中科院分区：
文献类型：
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作者：
Wu, Jun;Ueda, Kyosuke;Narushima, Takayuki
无定形磷酸钙（ACP）在钛种植体表面的涂层由于其在体内的溶解性而成为一种很有前途的增强骨形成能力的技术。手术部位感染是与植入器械相关的严重并发症之一。为了在钛种植体表面实现抗菌和成骨的双重功能，制备了掺银ACP涂层。ACP涂层膜预期用作Ag的载体。Ta的加入抑制了Ag-ACP涂膜的溶解速率，扩大了其潜在的应用。采用射频磁控溅射法在钛基片上制备了Ag和Ta共掺杂的ACP薄膜。溅射靶是热压烧结的压块，具有相同的Ag浓度10摩尔%和不同的Ta浓度（0、0.8和8.0摩尔%），同时RF功率从8改变到50 W。随着射频功率的增加，涂层中的Ag浓度降低。制备的ACP涂层致密、光滑，其组成元素（P、Ca、Ag和Ta）沿深度方向沿着均匀分布。此外，无论Ta浓度如何，Ag都以离子形式存在于ACP中。我们澄清了第一次，在溶液中的含银ACP涂层膜的溶解被抑制的Ta添加。抗菌活性通过Ag和Ta共掺杂的ACP涂层膜的连续溶解从Ag+离子的释放获得。
Coating of amorphous calcium phosphate (ACP) on titanium (Ti) implants is a promising technique for enhancing bone-forming ability because of its dissolution in vivo. Surgical site infection is one of the serious complications associated with implant devices. In order to achieve both the antibacterial properties and bone-forming ability on the surface of Ti implants, Ag-doped ACP coating films were fabricated. The ACP coating film is expected to work as a carrier of Ag. Ta was added to suppress the dissolution rate of the Ag-ACP coating films, which expands its potential applications. Ag and Ta co-doped ACP coating films were fabricated on Ti substrates by radiofrequency (RF) magnetron sputtering. The sputtering targets were hot-pressed sintered compacts with the same Ag concentration of 10 mol% and varying Ta concentration (0, 0.8, and 8.0 mol%), while the RF power was changed from 8 to 50 W. With increasing RF power, Ag concentration in the coating films decreased. The fabricated ACP coating films were dense and smooth, with their constituent elements (P, Ca, Ag, and Ta) distributed homogeneously along the depth direction. In addition, Ag existed as ions in the ACP regardless of Ta concentration. We clarified for the first time that the dissolution of Ag-containing ACP coating films in solution was suppressed by a Ta addition. Antibacterial activity was obtained from the release of Ag+ ions through continuous dissolution of Ag and Ta co-doped ACP coating films.