Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans
Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans
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DOI：
10.1128/cdli.10.2.332-335.2003
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发表时间：
2003-03-01
期刊：
影响因子：
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通讯作者：
van der Poll, T
中科院分区：
文献类型：
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作者：
de Fost, M;Hartskeerl, RA;van der Poll, T
热灭活致病性钩端螺旋体血清型Rachmati诱导γ干扰素（IFN-γ）和IFN-γ诱导细胞因子白细胞介素-12p40（IL-12 p40）和肿瘤坏死因子α在体外人全血中的产生。IFN-γ的产生在很大程度上依赖于IL-12。这些数据证实致病性钩端螺旋体可以刺激参与细胞免疫的I型细胞因子的产生。
Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-gamma) and the IFN-gamma-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-gamma was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.