A simple acromelic acid analog potentially useful for receptor photoaffinity labeling and biochemical studies
A simple acromelic acid analog potentially useful for receptor photoaffinity labeling and biochemical studies
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DOI：
10.1016/j.tetlet.2004.03.098
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发表时间：
2004-05-10
影响因子：
1.8
通讯作者：
Suzuki, M
中科院分区：
文献类型：
--
作者：
Furuta, K;Wang, GX;Suzuki, M
设计并合成了一种新型的含叠氮基苯基的丙烯酸类似物，作为研究红藻氨酸受体的生化探针。该类似物具有相当于天然丙烯酸A的生物活性，表明这两种化合物可能结合在同一目标生物分子上。为了将该探针用于光亲和标记实验，建立了将放射性碘引入到分子中的方法。(C)2004爱思唯尔有限公司。保留所有权利。
A novel acromelic acid analog possessing an azido-functionalized phenyl group was designed and synthesized as a biochemical probe for studies on kainoid receptors. The analog exerted a biological activity equivalent to natural acromelic acid A, suggesting that both compounds possibly bind to the same target biomolecule. In order to utilize the probe in photoaffinity labeling experiments, a procedure for the introduction of radioactive iodine into the molecule was established. (C) 2004 Elsevier Ltd. All rights reserved.