AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging.
AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging.
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DOI：
10.1039/c6fd00118a
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发表时间：
2017-02
影响因子：
3.4
通讯作者：
Jun Wang;Yinglong Wu;Fang Zeng;Shuailing Huang;Shuizhu Wu
中科院分区：
文献类型：
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作者：
Jun Wang;Yinglong Wu;Fang Zeng;Shuailing Huang;Shuizhu Wu
具有聚集诱导发射（AIE）特性的荧光团是用于化学传感和生物成像的有吸引力的和通用的工具。在此，我们设计并合成了一种具有增强细胞摄取能力的荧光发光系统CTPE-Tau。该体系具有斯托克斯位移大、细胞毒性低、光稳定性好等优点。此外，它已被成功地用于跟踪酯酶激活的牛磺酸释放和抑制细胞内的ROS，并显示出可跟踪的可视化治疗的巨大潜力。
Fluorophores with aggregation-induced emission (AIE) characteristics are attractive and versatile tools for both chemical sensing and biological imaging. Herein, we designed and synthesized a fluorescent light-up system CTPE-Tau with enhanced cellular uptake ability. The system possesses several advantages, such as a large Stokes shift, low cytotoxicity, and good photostability. Also, it has been successfully utilized to track esterase-activated release of taurine and to scavenge intracellular ROS, and shows great potential for trackable visualized therapy.