Affibody molecules as engineered protein drugs.
Affibody molecules as engineered protein drugs.
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DOI：
10.1038/emm.2017.35
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发表时间：
2017-03-24
影响因子：
12.8
通讯作者：
Kim KT
中科院分区：
文献类型：
--
作者：
Frejd FY;Kim KT
亲和体分子可用作诊断和治疗应用中的分子识别工具。有几项临床前研究报道了这类分子替代支架的诊断和治疗用途，小尺寸和易于工程化使得Affibody分子适合用于多特异性构建体，其中AffiMab是这样一种构建体，其提供了增强抗体以用于复杂的免疫治疗的选择。疾病
Affibody molecules can be used as tools for molecular recognition in diagnostic and therapeutic applications. There are several preclinical studies reported on diagnostic and therapeutic use of this molecular class of alternative scaffolds, and early clinical evidence is now beginning to accumulate that suggests the Affibody molecules to be efficacious and safe in man. The small size and ease of engineering make Affibody molecules suitable for use in multispecific constructs where AffiMabs is one such that offers the option to potentiate antibodies for use in complex disease.