Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland
Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland
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DOI：
10.1017/s0022029905001135
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发表时间：
2005-01-01
影响因子：
2.1
通讯作者：
Kacskovics, I
中科院分区：
文献类型：
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作者：
Mayer, B;Doleschall, M;Kacskovics, I
在反刍动物中，保护性免疫球蛋白通过初乳传递给新生儿，以介导母体免疫。免疫球蛋白从母体血浆穿过乳腺屏障进入初乳的转运具有高度选择性，只有IgG 1被大量转运。最近，我们分析了新生儿F-C受体（FcRn）的表达在绵羊乳腺分娩前后。在牛中重新分析该问题证实了我们先前的数据，表明FcRn在分娩前均匀定位于乳腺腺泡细胞中，然而在产犊后的模式中观察到显著差异，其中仅细胞的顶侧被强烈染色。FcRn在反刍动物乳腺腺泡上皮细胞中的存在及其在分娩前后分布的明显变化，表明FcRn在反刍动物初乳形成过程中IgG的转运中起重要作用。
In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts. We have recently analysed the expression of the neonatal F-C receptor (FcRn) in sheep mammary gland around parturition. Re-analysing this issue in bovine confirmed our previous data indicating that FcRn is homogeneously localized in the mammary gland acinar cells before parturition, however a remarkable difference was observed in the pattern after calving, where only the apical side of the cells was strongly stained. The presence of the FcRn in the acinar epithelial cells of the mammary gland and the obvious change in distribution before and after parturition indicate that FcRn plays an important role in the IgG transport during colostrum formation in ruminants.