Development of a Short Questionnaire to Assess the Quality of Life in Crohn's Disease and Ulcerative Colitis
Development of a Short Questionnaire to Assess the Quality of Life in Crohn's Disease and Ulcerative Colitis
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DOI：
10.1093/ecco-jcc/jju005
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发表时间：
2015-01-01
影响因子：
8
通讯作者：
Williams, John Gordon
中科院分区：
文献类型：
--
作者：
Alrubaiy, Laith;Cheung, Wai-Yee;Williams, John Gordon
背景和目的：大多数针对炎症性肠病（IBD）的疾病特异性生活质量（QoL）测量都是冗长且耗时的。在临床实践中还没有建立常规使用。我们设计这项研究是为了开发IBD的短期生活质量测量方法。方法：通过对既往有效问卷的文献回顾和对患者及专家的咨询，编制32项问卷——克罗恩病和溃疡性结肠炎问卷(CUCQ)-32。结构效度采用短表格12和EuroQol 5维度问卷和两种疾病严重程度测量（简单临床结肠炎活动指数和哈维-布拉德肖指数）进行。通过在两周内两次要求患者完成CUCQ问卷进行重测分析。结果：数据来自205例完成CUCQ-32的IBD患者。心理测量分析显示，Cronbach's a为0.88，项目总数相关性良好，不存在天花板或地板效应。逐步回归确定了8个项目占CUCQ-32方差的95%。结果CUCQ-8具有良好的内部一致性（Cronbach’s alpha = 0.84），重复性好（类内相关系数= 0.94），与EuroQol 5维度问卷（r = 0.58）和Short - table -12 （r = 0.65, r = 0.63）具有良好的相关性，对变化具有响应性（响应比为0.64，p值< 0.05）。结论：CUCQ-8是一份简短的问卷，在临床实践中有可能成为评估所有IBD患者生活质量的有效工具。
Background and aims: Most of the disease-specific quality of life (QoL) measures for inflammatory bowel disease (IBD) are lengthy and time consuming. None have been established for routine use in clinical practice. We designed this study to develop a short QoL measure in IBD.Methods: A 32-item questionnaire, the Crohn's and ulcerative colitis questionnaire (CUCQ)-32 was developed by reviewing the literature of the previously validated questionnaires and by consultation with patients and experts. Construct validity was carried out using the Short Form 12 and the EuroQol 5 dimensions questionnaires and two disease severity measures (the Simple Clinical Colitis Activity Index and the Harvey-Bradshaw Index). Test-retest analysis was done by asking patients to complete the CUCQ questionnaire twice within a period of two weeks.Results: Data were obtained from 205 patients with IBD who completed the CUCQ-32. Psychometric analysis showed that Cronbach's a was 0.88, item-total correlations were good, and there were no ceiling or flooring effects. Stepwise regression identified eight items that accounted for >95% of the variance in the CUCQ-32. The resulting CUCQ-8 demonstrated good internal consistency (Cronbach's alpha = 0.84), had good reproducibility (intraclass correlation coefficient = 0.94), was well correlated with the EuroQol 5 dimensions questionnaire (r = 0.58) and the Short Form-12 (r = 0.65 for physical component and r = 0.63 for mental component), and was responsive to change (responsiveness ratio was 0.64, p-value < 0.05).Conclusions: CUCQ-8 is a short questionnaire that has the potential to be an efficient tool for assessing the QoL of all patients with IBD in clinical practice.