WITHDRAWAL FOLLOWING COCAINE SELF-ADMINISTRATION DECREASES REGIONAL CEREBRAL METABOLIC-RATE IN CRITICAL BRAIN REWARD REGIONS
WITHDRAWAL FOLLOWING COCAINE SELF-ADMINISTRATION DECREASES REGIONAL CEREBRAL METABOLIC-RATE IN CRITICAL BRAIN REWARD REGIONS
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DOI：
10.1002/syn.890140110
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发表时间：
1993-05-01
期刊：
影响因子：
2.3
通讯作者：
KOOB, GF
中科院分区：
文献类型：
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作者：
HAMMER, RP;PIRES, WS;KOOB, GF
用定量[C-14]-2-脱氧葡萄糖放射自显影方法测定戒断后大鼠脑内局部葡萄糖代谢率(rCMR(GLC))。测定了62个脑区的RCMR(GLC)。正常大鼠连续置入空操作室12小时，训练后3小时自我给药的大鼠在有无可卡因的情况下进入操作室连续12小时。不能接触可卡因的动物在6小时后接受检查，而允许进入12小时可卡因狂欢的动物在可卡因后6小时或72小时接受检查。与幼稚状态相比，戒断时伏隔核、嗅结节、Calleja区岛、杏仁基底外侧核、中央杏仁核、内侧隔核、梨状皮质、扣带皮质、尾壳核、内侧丘脑、内侧丘脑、躯体感觉、听觉和运动皮质的代谢活性降低。这些影响通常在暴饮暴食后72小时比6小时更严重，在没有暴饮暴食的受过可卡因训练的动物中观察到中间值。这种反应与纹状体、嗅结节、梨状核、扣带回、躯体感觉和运动皮质在暴饮暴食期间的可卡因消耗量呈负相关。因此，可卡因的消耗量可以影响持续药物暴露后代谢抑制的程度。区域效应的模式表明，在可卡因戒断过程中，中脑边缘和头端锥体外区多巴胺终端区及其某些传出通路优先受到影响。在可卡因戒断过程中观察到的这些脑区基础代谢率的降低可能会随着时间的推移而变得更加严重，尽管某些行为动机反应明显恢复。
The quantitative [C-14]-2-deoxyglucose autoradiographic method was utilized to assess regional cerebral metabolic rate for glucose (rCMR(glc)) in rat brain during withdrawal from cocaine self-administration. RCMR(glc) was determined in 62 regions from brains of naive rats which were placed into an empty operant chamber for 12 hr continuously, and rats trained to self-administer cocaine during 3 hr training sessions and subsequently placed into the operant chamber for 12 hr continuously with or without access to cocaine. Animals placed into the chamber without access to cocaine were examined 6 hr later, while animals allowed access to the 12 hr cocaine binge were examined either 6 or 72 hr post-cocaine. Metabolic activity was reduced during withdrawal in the nucleus accumbens, olfactory tubercle, islands of Calleja region, basolateral and central amygdaloid nuclei, medial septum, piriform and cingulate cortices, rostral caudatoputamen, entopeduncular nucleus and the adjacent lateral hypothalamus, somatosensory, auditory, and motor cortices compared to the naive state. These effects were usually more severe at 72 than at 6 hr after binge exposure, with intermediate values observed in cocaine trained animals without binge exposure. The response was negatively correlated with the amount of cocaine consumed during binge exposure in the striatum, olfactory tubercle, piriform, cingulate, somatosensory, and motor cortices. Thus, the amount of cocaine consumed can affect the extent of metabolic depression after sustained drug exposure. The pattern of regional effects suggests that mesolimbic and rostral extrapyramidal dopamine terminal regions and certain of their efferent pathways are preferentially affected during cocaine withdrawal. The reduction of basal metabolic rate observed in these brain regions during cocaine withdrawal may become more severe with time despite the apparent recovery of certain behavioral-motivational responses.