FLUORESCENCE OF NON‐NEOPLASTIC, MAGNETIC RESONANCE IMAGING‐ENHANCING TISSUE BY 5‐AMINOLEVULINIC ACID: CASE REPORT
FLUORESCENCE OF NON‐NEOPLASTIC, MAGNETIC RESONANCE IMAGING‐ENHANCING TISSUE BY 5‐AMINOLEVULINIC ACID: CASE REPORT
复制标题
5-氨基乙酰丙酸对非肿瘤组织的磁共振成像荧光增强：病例报告
作者：
S. Miyatake;T. Kuroiwa;Y. Kajimoto;M. Miyashita;Hidekazu Tanaka;M. Tsuji
目的5-氨基乙酰丙酸在脑胶质瘤手术中的应用已被证实是可行的。在这项研究中，我们描述了三个案例，在这些案例中，即使是坏死周围组织也可以被识别为荧光阳性。方法对3例中枢神经系统疾病患者行5-氨基乙酰丙酸荧光治疗。其中两人被诊断为放射性坏死，另一人被诊断为神经退行性脱髓鞘疾病。结果在所有病例中，至少部分Gd强化区可标记为荧光阳性，而坏死区中心为阴性。组织学上，每例细胞均有明显的细胞浸润，呈荧光活性。结论用5-氨基酮戊酸标记恶性肿瘤和放射性坏死或神经退行性疾病的坏死区均为荧光阳性。
OBJECTIVEIt has been established that fluorescence-guided resection using 5-aminolevulinic acid is useful in glioma surgery. In this study, we describe three cases in which even perinecrotic tissue could be recognized as fluorescence positive. METHODSThree cases of central nervous system disease, showing gadolinium enhancement on magnetic resonance imaging scans, were operated on with the aid of fluorescence derived from 5-aminolevulinic acid. Two of these were diagnosed as radiation necrosis and the other as a neurodegenerative demyelinating disease. RESULTSIn all cases, at least some parts of the gadolinium-enhanced area could be labeled as fluorescence positive, whereas centers of necrotic tissue were negative for fluorescence. Histologically, cell infiltration was marked in each case that showed fluorescence activity. CONCLUSIONBoth malignant tumors and the perinecrotic area in radiation necrosis or neurodegenerative disease can be labeled as fluorescence positive using 5-aminolevulinic acid.