Leptin at 14 y of age: an ongoing story
Leptin at 14 y of age: an ongoing story
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DOI：
10.3945/ajcn.2008.26788b
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发表时间：
2009-03-01
影响因子：
7.1
通讯作者：
Friedman, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Friedman, Jeffrey M.
Ob基因及其基因产物瘦素的克隆导致了维持脂肪储存恒定的强大生理系统的阐明。瘦素是一种由脂肪组织分泌的多肽激素，调节脂肪组织的质量和能量平衡。瘦素基因的隐性突变与老鼠和一些人类的大规模肥胖有关，这为肥胖奠定了基因基础。瘦素在血液中循环，作用于大脑，调节食物摄入量和能量消耗。当脂肪量减少时，血浆瘦素浓度会降低，这会刺激食欲，抑制能量消耗，直到脂肪量恢复。当脂肪量增加时，瘦素浓度就会增加，这会抑制食欲，直到体重减轻。该系统维持脂肪组织质量的动态平衡控制。Am J Clin Nutr 2009；89(Suppl)：973 S-9S。
The cloning of the ob gene and its gene product leptin has led to the elucidation of a robust physiologic system that maintains constancy of fat stores. Leptin is a peptide hormone secreted by adipose tissue and regulates adipose tissue mass and energy balance. Recessive mutations in the leptin gene are associated with massive obesity in mice and in some humans, which establishes a genetic basis for obesity. Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass decreases, plasma leptin concentrations decrease, which stimulates appetite and suppresses energy expenditure until fat mass is restored. When fat mass increases, leptin concentrations increase, which suppresses appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass. Am J Clin Nutr 2009; 89(suppl): 973S-9S.