Local and Global Fiber Tractography in Patients with Epilepsy
Local and Global Fiber Tractography in Patients with Epilepsy
复制标题
DOI：
10.3174/ajnr.a3752
复制
发表时间：
2014-02-01
影响因子：
3.5
通讯作者：
Mader, I.
中科院分区：
文献类型：
--
作者：
Anastasopoulos, C.;Reisert, M.;Mader, I.
背景和目的：纤维束描记术越来越多地用于濒危纤维束的术前评估。从临床的角度来看，需要一个准确和方法上透明的程序。我们的目的是评估最近描述的全球跟踪算法相比，与其他已建立的方法，如确定性和概率tractography.MATERIALS和方法：20例患者，癫痫病灶切除的候选人，进行了更高的角分辨率的扩散成像为基础的纤维束。种子点的创建没有手动偏见，主要是由FreeSurfer和基于体素的地图集。我们集中在2个重要的纤维束，即下行运动通路和光辐射。术后，预测的纤维路线的准确性控制结构磁共振成像和造成的功能deficits.Results：在3个评价方法，全球跟踪是唯一的方法能够重建的全部范围内的下行运动通路，包括皮质延髓纤维从该地区的脸表示。然而，概率纤维束成像更好地描述了视辐射，特别是迈耶环。确定性算法执行不充分。CONCLUSIONS：概率方法似乎是计算时间和有效性之间的最佳平衡，似乎是最好的选择，在大多数情况下，特别是光学辐射。然而，如果要详细描述纤维解剖结构，并且涉及纤维束交叉，则应首选计算耗时的全局跟踪。
BACKGROUND AND PURPOSE: Fiber tractography is increasingly used in the preoperative evaluation of endangered fiber bundles. From a clinical point of view, an accurate and methodologically transparent procedure is desired. Our aim was to evaluate the recently described global tracking algorithm compared with other established methods, such as deterministic and probabilistic tractography.MATERIALS AND METHODS: Twenty patients, candidates for excision of epileptogenic lesions, were subjected to higher-angular resolution diffusion imaging-based fiber tractography. Seed points were created without manual bias, predominantly by FreeSurfer and voxel-based atlases. We focused on 2 important fiber bundles, namely the descending motor pathways and the optic radiation. Postoperatively, the accuracy of the predicted fiber route was controlled by structural MR imaging and by inflicted functional deficits.RESULTS: Among the 3 evaluated methods, global tracking was the only method capable of reconstructing the full extent of the descending motor pathways, including corticobulbar fibers from the area of face representation. Still, probabilistic tractography depicted the optic radiation better, especially the Meyer loop. The deterministic algorithm performed less adequately.CONCLUSIONS: The probabilistic method seems to be the best balance between computational time and effectiveness and seems to be the best choice in most cases, particularly for the optic radiation. If, however, a detailed depiction of the fiber anatomy is intended and tract crossings are implicated, then the computationally time-consuming global tracking should be preferred.