A Novel Way to Measure and Predict Development: A Heuristic Approach to Facilitate the Early Detection of Neurodevelopmental Disorders.
A Novel Way to Measure and Predict Development: A Heuristic Approach to Facilitate the Early Detection of Neurodevelopmental Disorders.
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DOI：
10.1007/s11910-017-0748-8
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发表时间：
2017-05
影响因子：
5.6
通讯作者：
BEE-PRI Study Group
中科院分区：
文献类型：
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作者：
Marschik PB;Pokorny FB;Peharz R;Zhang D;O'Muircheartaigh J;Roeyers H;Bölte S;Spittle AJ;Urlesberger B;Schuller B;Poustka L;Ozonoff S;Pernkopf F;Pock T;Tammimies K;Enzinger C;Krieber M;Tomantschger I;Bartl-Pokorny KD;Sigafoos J;Roche L;Esposito G;Gugatschka M;Nielsen-Saines K;Einspieler C;Kaufmann WE;BEE-PRI Study Group
已有大量研究集中于早期人类发展的各个方面和领域。然而，在处理神经发育障碍时，特别是那些仅在婴儿后期或甚至在儿童时期表现出临床症状的神经发育障碍，出生后早期发育存在明显的盲点。这一早期发育期可能代表着研究这些疾病的重要时间框架，但历史上受到的研究关注要少得多。我们相信，只有综合的跨学科方法才能使我们能够在很小的时候就检测和描述特定神经发育障碍的特定参数，以改进早期发现/诊断，使前瞻性研究能够实现，并最终促进早期干预的随机试验。在这篇文章中，我们提出了一个动态框架，用于表征与婴儿和儿童发育中的特定障碍相关的神经功能生物标志物。我们将这种自动检测命名为指纹模型，这表明了一种可能的方法，可以准确和早期地识别神经发育障碍。
Substantial research exists focusing on the various aspects and domains of early human development. However, there is a clear blind spot in early postnatal development when dealing with neurodevelopmental disorders, especially those that manifest themselves clinically only in late infancy or even in childhood. This early developmental period may represent an important timeframe to study these disorders but has historically received far less research attention. We believe that only a comprehensive interdisciplinary approach will enable us to detect and delineate specific parameters for specific neurodevelopmental disorders at a very early age to improve early detection/diagnosis, enable prospective studies and eventually facilitate randomised trials of early intervention. In this article, we propose a dynamic framework for characterising neurofunctional biomarkers associated with specific disorders in the development of infants and children. We have named this automated detection ‘Fingerprint Model’, suggesting one possible approach to accurately and early identify neurodevelopmental disorders.