One-step solvothermal synthesis of highly water-soluble, negatively charged superparamagnetic Fe3O4 colloidal nanocrystal clusters
One-step solvothermal synthesis of highly water-soluble, negatively charged superparamagnetic Fe3O4 colloidal nanocrystal clusters
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DOI：
10.1039/c3nr00931a
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发表时间：
2013-01-01
期刊：
影响因子：
6.7
通讯作者：
Su, Yongping
中科院分区：
文献类型：
--
作者：
Gao, Jining;Ran, Xinze;Su, Yongping
采用改进的一步溶剂热法成功合成了平均直径为195 nm的高电荷亲水性超顺磁性Fe3O4胶体纳米晶簇。采用含有磺酸基和羧酸基的阴离子聚（4-苯乙烯磺酸-共马来酸）钠盐作为稳定剂。用透射电镜和动态光散射对不同实验条件下合成的团簇进行了表征；研究发现，反应混合物中聚电解质稳定剂和铁源的浓度对粒径分布和水分分散性有显著影响。提出并讨论了一种限制成核和聚集过程的新型凝胶状大分子网络的可能机制。在2 ~ 11的实验pH范围内，胶体纳米晶体团簇保持负电荷，在磷酸盐缓冲盐水（PBS）和乙醇中也表现出较高的胶体稳定性。这些高度胶体稳定的超顺磁性Fe3O4团簇在生物分离、靶向药物递送和光子学方面具有潜在的应用前景。
Highly charged hydrophilic superparamagnetic Fe3O4 colloidal nanocrystal clusters with an average diameter of 195 nm have been successfully synthesized using a modified one-step solvothermal method. Anionic polyelectrolyte poly(4-styrenesulfonic acid-co-maleic acid) sodium salt containing both sulfonate and carboxylate groups was used as the stabilizer. The clusters synthesized under different experimental conditions were characterized with transmission electron microscopy and dynamic light scattering; it was found that the size distribution and water dispersity were significantly affected by the concentration of the polyelectrolyte stabilizer and iron sources in the reaction mixtures. A possible mechanism involving novel gel-like large molecular networks that confined the nucleation and aggregation process was proposed and discussed. The colloidal nanocrystal clusters remained negatively charged in the experimental pH ranges from 2 to 11, and also showed high colloidal stability in phosphate buffered saline (PBS) and ethanol. These highly colloidal stable superparamagnetic Fe3O4 clusters could find potential applications in bioseparation, targeted drug delivery, and photonics.