Cerebellar spongiform degeneration induced by acute lithium intoxication in the rat
Cerebellar spongiform degeneration induced by acute lithium intoxication in the rat
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DOI：
10.1016/s0304-3940(97)13461-9
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发表时间：
1997-03-07
影响因子：
2.5
通讯作者：
Hildebrand, J
中科院分区：
文献类型：
--
作者：
Dethy, S;Manto, M;Hildebrand, J
小脑综合征已被描述后，急性锂中毒的人。神经病理学研究表明小脑神经元丢失和海绵状组织增生。我们描述了一种急性锂诱导的小脑变性的动物模型。在给予氯化锂（250 mg/kg，i. p.）后5小时，14只大鼠中有7只的小脑白色物质表现出广泛的海绵状改变。微透析法测定大鼠小脑皮质多巴胺（DA）、羟基-3-甲氧基苯乙酸（HVA）和5-羟基-3-吲哚乙酸（5-HIAA）的基础浓度。这些代谢物不受急性锂中毒的影响，表明小脑毒性不是由于多巴胺能或胆碱能神经传递的改变。(C)1997 Elsevier Science爱尔兰有限公司
Cerebellar syndrome has been described after acute lithium intoxication in human. Neuropathological studies have demonstrated neuronal loss and spongiosis in the cerebellum. We describe an animal model of acute lithium-induced cerebellar degeneration. Five hours following administration of lithium chloride (250 mg/kg, i.p.), the cerebellar white matter of seven rats out 14 exhibited extensive spongiform changes. Microdialysis study in the rat cerebellar cortex demonstrated basal concentrations of dopamine (DA), hydroxy-3-methoxyphenylacetic acid (HVA) and 5-hydroxy-3-indolacetic acid (5-HIAA). These metabolites were unaffected by acute lithium intoxication suggesting that the cerebellar toxicity is not due to a modification of dopaminergic or serotoninergic neurotransmission. (C) 1997 Elsevier Science Ireland Ltd.