COMPARISON OF HUMAN TRANSCALLOSAL RESPONSES EVOKED BY MAGNETIC COIL AND ELECTRICAL-STIMULATION
COMPARISON OF HUMAN TRANSCALLOSAL RESPONSES EVOKED BY MAGNETIC COIL AND ELECTRICAL-STIMULATION
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DOI：
10.1016/0168-5597(89)90030-0
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发表时间：
1989-11-01
期刊：
影响因子：
--
通讯作者：
CRACCO, JB
中科院分区：
文献类型：
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作者：
CRACCO, RQ;AMASSIAN, VE;CRACCO, JB
用磁线圈（MC）刺激对侧额叶皮层的同源部位，诱发人的经胼胝体反应（TCR），并与局灶性阳极刺激的结果进行比较。在MC刺激下，TCR由起始潜伏期为8.8-12.2毫秒、持续时间为7-15毫秒、振幅高达20 μ V的初始正波组成，有时随后是宽的低振幅负波。与阳极刺激，获得了类似的反应，其中正波是类似的潜伏期和最大振幅，但有一个更大的持续时间。在阳极刺激下，不仅TCR阈值低于对侧运动的阈值，而且在低于运动阈值的强度下达到相当大的尺寸。与MC刺激，对侧手臂运动和头皮皮质运动电位观察时，MC向后移位到中央沟。与阳极刺激不同，MC诱发的TCr通常不会出现颞肌的明显EMG电位，并且与受试者不适无关。TCR提供了关于胼胝体投射神经元、其轴突和受体皮质中的跨突触过程的功能完整性的独特信息。这些信息可能被证明是有用的内在脑机制的评价和建立皮质的活力。
Human transcallosal responses (TCRs) were elicited by focal magnetic coil (MC) stimulation of homologous sites in contralateral frontal cortex and compared with those to focal anodic stimulation. With MC stimulation, the TCR consisted of an initially positive wave with an onset latency of 8.8-12.2 msec, a duration of 7-15 msec, and an amplitude which reached up to 20 .mu.V, sometimes followed by a broad low amplitude negative wave. With anodic stimulation, a similar response was obtained in which the positive wave was similar in latency and maximum amplitude, but had a greater duration. With anodic stimulation, not only was the TCR threshold below that for contralateral movement, but it reached substantial size at intensities below motor threshold. With MC stimulation, contralateral arm movement and scalp corticomotor potentials were observed when the MC was displaced posteriorly towards the central sulcus. Unlike with anodic stimulation, the MC evoked TCr was usually not preceded by a prominent EMG potential from temporalis muscle and was not associated with subject discomfort. The TCR provides unique information concerning the functional integrity of callosal projection neurons, their axons and transsynaptic processes in recipient cortex. This information may prove useful in the evaluation of intrinsic cerebral mechanisms and in establishing cortical viability.