Kinetic resolution of iodophenylethanols by Candida antarctica lipase and their application for the synthesis of chiral biphenyl compounds
Kinetic resolution of iodophenylethanols by Candida antarctica lipase and their application for the synthesis of chiral biphenyl compounds
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DOI：
10.1016/j.tetasy.2010.05.008
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发表时间：
2010-04-30
影响因子：
--
通讯作者：
Porto, Andre L. M.
中科院分区：
文献类型：
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作者：
Rocha, Lenilson C.;Rosset, Isac G.;Porto, Andre L. M.
(+/-)-碘苯乙醇的动力学拆分是使用来自南极洲念珠菌的脂肪酶进行的，在某些情况下，对映体过量很高（高达 >98%）。通过酶解工艺生产的对映体富集的 (S)-碘苯基乙醇用于通过 Suzuki 反应合成手性联苯化合物，收率良好 (63-65%)。 (C) 2010 Elsevier Ltd. 保留所有权利。
The kinetic resolution of (+/-)-iodophenylethanols was carried out using lipase from Candida antarctica and in some cases the enantiomeric excesses were high (up to >98%). Enantiomerically enriched (S)-iodophenylethanols produced by the enzymatic resolution process were used in the synthesis of chiral biphenyl compounds by the Suzuki reaction with good yields (63-65%). (C) 2010 Elsevier Ltd. All rights reserved.