Evolutionary rewiring of bacterial regulatory networks.
Evolutionary rewiring of bacterial regulatory networks.
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DOI：
10.15698/mic2015.07.215
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发表时间：
2015-07-06
期刊：
影响因子：
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通讯作者：
Jackson RW
中科院分区：
文献类型：
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作者：
Taylor TB;Mulley G;McGuffin LJ;Johnson LJ;Brockhurst MA;Arseneault T;Silby MW;Jackson RW
细菌已经进化出复杂的调控网络，使多种细胞内和细胞外信号的整合，以协调对环境变化的反应。然而，我们对监管系统如何运作和演变的了解仍然相对有限。由于过去基因复制、分化和水平基因转移的循环，不同网络的组成部分之间往往存在广泛的同源性，这增加了串扰或冗余的可能性。因此，进化的弹性是建立在基因网络中的-调节器之间的同源性可能允许快速拯救基因组中遥远区域的失去的调节功能。在我们最近的研究中[Taylor，et al. Science（2015），347（6225）]，我们发现促进通路之间串扰的突变可以促进基因网络进化，但这种突变会带来严重的多效性代价。从这项工作中产生的是围绕这种现象如何发生的一些问题。
Bacteria have evolved complex regulatory networks that enable integration of multiple intracellular and extracellular signals to coordinate responses to environmental changes. However, our knowledge of how regulatory systems function and evolve is still relatively limited. There is often extensive homology between components of different networks, due to past cycles of gene duplication, divergence, and horizontal gene transfer, raising the possibility of cross-talk or redundancy. Consequently, evolutionary resilience is built into gene networks - homology between regulators can potentially allow rapid rescue of lost regulatory function across distant regions of the genome. In our recent study [Taylor, et al. Science (2015), 347(6225)] we find that mutations that facilitate cross-talk between pathways can contribute to gene network evolution, but that such mutations come with severe pleiotropic costs. Arising from this work are a number of questions surrounding how this phenomenon occurs.