Cardiac lymph flow in conscious dogs.
Cardiac lymph flow in conscious dogs.
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意识清醒的狗的心脏淋巴液流动。
DOI：
10.1152/ajpheart.1979.237.3.h311
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
M. Entman
中科院分区：
文献类型：
--
作者：
L. Michael;R. Lewis;T. Brandon;M. Entman
狗的心脏淋巴管被插入，外置的导管允许在清醒状态下慢性收集淋巴长达3wk。描述了手术方法和技术中的固有困难：d.对照状态下14只犬的心脏淋巴流量在0.45-5.6ml/h之间。将封堵器和血流探头放置在回旋支冠状动脉(CFX)上，将超声节段长度的晶体放置在4只犬的左心室游离壁。在这些清醒的狗中，阻断CFX导致淋巴流量在前半小时内比对照组下降了46%。闭塞血管的再灌注导致淋巴流量比对照组增加高达67%。一些已知对心血管系统有影响的精选药物显示了对心脏淋巴流量的影响。心脏淋巴流量：异丙肾上腺素增加42+/-11%，RO2-2985增加118+/-8%，维拉帕米增加101+/-10%，心得安无明显变化。心脏淋巴管插管的清醒犬可以为进一步研究心脏代谢和生理的复杂性提供一个模型，而不受麻醉和手术应激的干扰。
The cardiac lymphatic duct was cannulated in dogs and the exteriorized cannula allowed chronic collection of lymph during the awake state for as long as 3 wk. The surgical methodology and inherent difficulties in the technique are describ:d. Cardiac lymph flow ranged from 0.45--5.6 ml/h in the control state in 14 dogs. An occluding device and flow probe were placed on the circumflex coronary artery (CFX); ultrasonic segment length crystals were placed in the left ventricular free wall in 4 dogs. Occlusion of the CFX in these conscious dogs caused lymph flow to fall as great as 46% below control during the 1st half-hour. Reperfusion of the occluded vessel caused an increase in lymph flow as great as 67% above control. The effect on cardiac lymph flow was demonstrated for a few select drugs that have known effects on the cardiovascular system. Cardiac lymph flow was altered from control as follows: isoproterenol, 42 +/- 11% increase; RO 2-2985, 118 +/- 8% increase; verapamil, 101 +/- 10% increase; propranolol caused no significant change. The conscious dog with cardiac lymph vessel cannulated should provide a model to further study the complexities of cardiac metabolism and physiology without interference of anesthesia and surgical stress.