The entorhinal cortex is involved in conditioned odor and context aversions.
The entorhinal cortex is involved in conditioned odor and context aversions.
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DOI：
10.3389/fnins.2015.00342
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发表时间：
2015
影响因子：
4.3
通讯作者：
Majchrzak M
中科院分区：
文献类型：
--
作者：
Ferry B;Herbeaux K;Javelot H;Majchrzak M
在自然环境中，对特定食物来源的回避主要是由先前的摄入经验决定的，在此期间，诸如食物气味的感官刺激通过简单的联想条件学习变得令人厌恶。条件性气味厌恶学习（COA）是一种食物条件化范式，其产生于无味气味溶液（条件刺激，CS）和其摄入后的胃部不适（非条件刺激，US）之间的关联。在本实验条件下，COA的获得也导致了对CS呈现的语境的厌恶（条件性语境厌恶，CCA）的获得。以往的研究表明，内嗅皮层（EC）参与了COA获得和情境恐惧条件化的记忆过程，但EC损伤是否影响CCA的获得还未见报道。为此，雄性Long-Evans大鼠双侧EC病变接受CS-US配对在一个特定的背景下，不同的刺激间隔（ISI）。结果表明，在EC损伤大鼠中获得的具有长ISI的COA的建立与CCA学习的改变有关。由于ISI已被认为是气味和上下文的美国协会的决定因素，我们的研究结果表明，EC参与的过程中，控制这两个协会相对于ISI的持续时间。
In a natural environment, avoidance of a particular food source is mostly determined by a previous intake experience during which sensory stimuli such as food odor, become aversive through a simple associative conditioned learning. Conditioned odor aversion learning (COA) is a food conditioning paradigm that results from the association between a tasteless scented solution (conditioned stimulus, CS) and a gastric malaise (unconditioned stimulus, US) that followed its ingestion. In the present experimental conditions, acquisition of COA also led to acquisition of aversion toward the context in which the CS was presented (conditioned context aversion, CCA). Previous data have shown that the entorhinal cortex (EC) is involved in the memory processes underlying COA acquisition and context fear conditioning, but whether EC lesion modulates CCA acquisition has never be investigated. To this aim, male Long-Evans rats with bilateral EC lesion received CS-US pairings in a particular context with different interstimulus intervals (ISI). The results showed that the establishment of COA with long ISI obtained in EC-lesioned rats is associated with altered CCA learning. Since ISI has been suggested to be the determining factor in the odor- and context-US association, our results show that the EC is involved in the processes that control both associations relative to ISI duration.