Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
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DOI：
10.1016/j.mad.2006.03.002
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发表时间：
2006-08-01
影响因子：
5.3
通讯作者：
Buffenstein, Rochelle
中科院分区：
文献类型：
--
作者：
Hulbert, A. J.;Faulks, Sally C.;Buffenstein, Rochelle
爱达荷 (Id) 和马朱罗 (Ma) 这两个小鼠品系均源自野生捕获的祖先，此前已被证明与遗传异质的实验室小鼠品系 (DC) 相比，圈养小鼠的寿命更长。我们已经检查了小家鼠物种内的膜脂肪成分是否随着寿命的变化而变化，其方式与之前在哺乳动物物种之间所证明的方式类似。与 DC 小鼠相比，这些长寿小鼠系的肌肉和肝脏磷脂中高度多不饱和 omega-3 二十二碳六烯酸的含量减少，因此它们的膜不太可能受到过氧化损伤。这些小鼠品系的最大寿命和膜过氧化指数之间的关系与之前在一般哺乳动物中观察到的相似。这表明抗过氧化膜可能是延长寿命的重要组成部分。 (c) 2006 Elsevier Ireland Ltd. 保留所有权利。
Two lines of mice, Idaho (Id) and Majuro (Ma), both derived from wild-trapped progenitors, have previously been shown to have extended lifespans in captivity when compared to a genetically heterogenous laboratory line of mice (DC). We have examined whether membrane fatty composition varies with lifespan within the species Mus musculus in a similar manner to that previously demonstrated between mammal species. Muscle and liver phospholipids from these long-living mice lines have a reduced amount of the highly polyunsaturated omega-3 docosahexaenoic acid compared to the DC mice, and consequently their membranes are less likely to peroxidative damage. The relationship between maximum longevity and membrane peroxidation index is similar for these mice lines as previously observed for mammals in general. It is suggested that peroxidation-resistant membranes may be an important component of extended longevity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.